Assessing the Effect of Leptin on Liver Damage in Case of Hepatic Injury Associated with Paracetamol Poisoning

Table 2

ALT and AST levels measured in the rat sera.

Group	ALT (U/L)	AST (U/L)	TNF-α (pg/mL)
Control	46.54 ± 11.67^a	88.58 ± 21.03^a	41.31 ± 2.36^a
LEP 20 µg/kg	55.25 ± 13.99^a.b	87.65 ± 11.08^a	48.31 ± 9.67^a
PARA 2 g/kg	196.14 ± 53.80^d	236.30 ± 37.18^c	154.88 ± 34.14^b
PARA 2 g/kg + LEP 10 µg/kg	80.75 ± 11.67^b	117.26 ± 25.31^a	43.25 ± 9.53^a
PARA 2 g/kg + LEP 20 µg/kg	122.83 ± 39.81^c	176.86 ± 57.44^b	50.75 ± 12.25^a

Group 1: the control group, Group 2: 20 µg/kg leptin. Group 3: 2 g/kg paracetamol. Group 4: 2 g/kg paracetamol + 10 µg/kg leptin. Group 5: 2 g/kg paracetamol + 20 µg/kg leptin. LEP: the group receiving leptin, PARA: the group receiving paracetamol. The results were analyzed using the post-hoc Duncan technique in the one-way ANOVA test. comparison of the control group and paracetamol group, comparison of the control group and treatment group, comparison of the paracetamol group and the treatment group (PARA 2 g/kg + LEP 10 µg/kg), comparison of the paracetamol group and the treatment group (PARA 2 g/kg + LEP 20 µg/kg), was considered significant.