Table 3: Outcome of patients according to Siewert classification.

OutcomeSiewert 1Siewert 2Siewert 3Siewert
2 + 3
Siewert
1 versus 2 versus 3
Siewert
1 versus (2 + 3)

Mean
 OS ± SE (months)70 ± 11.753.2 ± 7.261.3 ± 18.856.7 ± 7.20.180.14
Mean
 ORR ± SE (%)27.3 ± 13.476.5 ± 8.320 ± 17.962 ± 7.90.0520.047
Mean
 CRLR ± SE (%)19.2 ± 10.141.8 ± 10.1037.5 ± 9.20.270.35
Mean
 CRNR ± SE (%)045.1 ± 10.720 ± 17.941.3 ± 9.70.080.028
Mean
 CRMR ± SE (%)9.1 ± 8.765.2 ± 9.775 ± 21.760.2 ± 8.90.0170.012
pCR, (%)
 Yes 6 (40)8 (21.1)2 (40)10 (23.3)0.310.21
 No9 (60)30 (78.9)3 (60)33 (76.7)
 NA ( = 10)
Cause of death, (%)
 Disease progression2 (33.3)25 (78.1)1 (50)26 (76.5)0.090.06
 Complication3 (50)3 (9.4)1 (50)4 (11.8)
 Other causes1 (16.7)4 (12.5)04 (11.8)
Cause of death, (%)
 Disease progression2 (33.3)25 (78.1)1 (50)26 (76.5)0.070.03
 Other causes4 (66.7)7 (21.9)1 (50)8 (23.5)

OS: overall survival; ORR: overall relapse rate; SE: standard error; CRLR: cumulative rate of local relapse; CRNR: cumulative rate of nodal relapse; CRMR: cumulative rate of metastatic relapse; pCR: pathological complete response; NA: nonavailable.