Rescue Therapy with a Proton Pump Inhibitor Plus Amoxicillin and Rifabutin for Helicobacter pylori Infection: A Systematic Review and Meta-Analysis

Table 2

Characteristics of studies without included meta-analysis.

Study, year	Age	Location	Regimen^†	Duration (day)	H. pylori infection diagnosis/rechecking^●	Eradication rate by ITT^Ф	Eradication rate by PP^◊	Side effects	Discounting	Therapy	MINORS score
Toracchio et al. [22], 2005	Adult	Italy	PRA	10	RUT and C13-UBT	Group 1: 87.5% (366/420) Group 2: 78.5% (82/104)	Group 1: 100% (366/366) Group 2: 82.2% (82/10)	1	—	First or second	18
Gesbert et al. [23], 2003	Adult	Spain	ORA	14	C13-UBT/C13-UBT	79% (11/14)	79% (11/14)	5	0	Third	13
Borody et al. [9], 2006	Adult	Australia	LRA	12	C13-UBT	90.8% (118/130)	90.8% (118/130)	52	—	Second, third, fourth	14
González Carro et al. [24], 2007	Adult	Spain	PRA	10	C13-UBT/C13-UBT	61% (55/92)	62.20% (55/90)	2	2	Third	13
Veldhuyzen van Zanten et al. [25], 2010	Adult	Canada	PPI-RA	7	H, C/H, UBT	63% (10/16)	67% (10/15)	—	1	Rescue	9
Perri et al. [26], 2000	Adult	Italy	PRA	7	C13-UBT/C13-UBT	71.00% (29/41)	74.00% (29/39)	1	2	Rescue	13
Bock et al. [27], 2000	Adult	Germany	LRA	7	C13-UBT/C13-UBT	72% (18/25)	86% (18/21)	0	4	Rescue	10
Zullo et al. [28], 2010	Adult	Italy	ORA	10	C13-UBT/C13-UBT	76.40% (13/17)	79.50% (13/16)	10	3	Third	14
Van der Poorten and Katelaris [29], 2007	Adult	Australia	PPI-RA	10	H, RUT, C13-UBT/C13-UBT	72% (48/67)	76% (48/63)	7	4	Rescue	10
Perri et al. [30], 1998	Adult	Italy	RAP	7	C13-UBT/C13-UBT	79.00% (22/28)	79.00% (22/28)	1	0	Rescue	14
Gisbert et al. [31], 2014	Adult	Spain	PPI-RA	10	—/C13-UBT	52%	53%	51	10	Fourth	NA
Borody et al. [32], 2012	Adult	Australia	ORA	14	—/UBT	92% (52/56)	94% (52/55)	—	4	Rescue	NA
Moon et al. [33], 2012	Adult	Korea	LRA	12	—	92.2% (47/51)	94% (47/50)	—	1	Third	15

E: esomeprazole, O: omeprazole, PPI: proton pump inhibitor, P: pantoprazole, L: lansoprazole, A: amoxicillin, and R: rifabutin.
^●C: culture; UBT: urea breath test; H: histology; RUT: rapid urease test.
^ФITT: intention to treat; ^◊PP: per protocol.
Rescue: rescue therapy, second: second-line therapy, third: three-line therapy, fourth: fourth-line therapy.
“—”: not reported; NA: not assessed.
Sign: 
Toracchio et al. (2005) [22]: patients in group 1 without previous exposure to triple therapy; patients in group 2 had already received one course of triple therapy.
Two abstracts, Gisbert et al. (2014) [31] and Borody et al. (2012) [32], quality cannot be assessed because we do not know the detailed method of studies.