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Gastroenterology Research and Practice
Volume 2015, Article ID 490183, 12 pages
Review Article

Diagnosis of Irritable Bowel Syndrome: Role of Potential Biomarkers

1Emergency Department, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia
2Department of Gastroenterology, Clinical Hospital Centre Rijeka, Krešimirova 42, 51000 Rijeka, Croatia
3Department of Psychology, Faculty of Humanities and Social Sciences, University of Rijeka, Sveučilišna Avenija 4, 510000 Rijeka, Croatia
4Department of Gastroenterology and Hepatology, University Clinical Centre Tuzla, Trnovac bb, 76000 Tuzla, Bosnia and Herzegovina

Received 16 March 2015; Accepted 26 May 2015

Academic Editor: Eiji Sakai

Copyright © 2015 Ivana Plavšić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Irritable bowel syndrome is a disorder diagnosed on symptom-based criteria without inclusion of any objective parameter measurable by known diagnostic methods. Heterogeneity of the disorder and overlapping with more serious organic diseases increase uncertainty for the physician’s work and increase the cost of confirming the diagnosis. This paper is an attempt to summarize the efforts to find adequate biomarkers for irritable bowel syndrome, which should shorten the time to diagnosis and reduce the cost. Most of the reviewed papers were observational studies from secondary care institutions. Since publication of the Rome III criteria in 2006, most recent studies use these for the recruitment of IBS patients. This is a positive step forward as future studies should use the same criteria, facilitating comparison of their results. Among the studied biomarkers, most evidence is provided for fecal calprotectin. Cutoff values for fecal calprotectin have still to be investigated prior to inclusion in the irritable bowel syndrome diagnostic algorithm.