The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice

Figure 1

Resveratrol pretreatment attenuates ConA-induced autoimmune hepatitis. Liver histopathology in ConA-induced liver injury. Liver samples were taken from mice treated with ConA (20 mg/kg) and mice treated with ConA and resveratrol (10, 20, and 30 mg/kg, resp., daily oral administration × 14 days). Sections were stained with H&E. (a) Saline group; (b) resveratrol-alone group; (c) ConA group: liver section from a mouse from the ConA-treated group showing extensive liver focal necrosis, portal infiltration, and interface hepatitis. H&E, magnification ×100; ((d)–(f)) ConA + Res (10 mg/kg); ConA + Res (20 mg/kg); ConA + Res (30 mg/kg): liver section from a mouse treated with ConA and resveratrol, and liver histology shows only a minimal grade of cellular infiltration and hepatocyte damage. H&E, magnification ×100. (g) The necrotic areas were analyzed with Image-pro Plus 6.0, indicating statistical significance among groups.

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