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Gastroenterology Research and Practice
Volume 2015, Article ID 518018, 7 pages
http://dx.doi.org/10.1155/2015/518018
Clinical Study

Improved Helicobacter pylori Eradication Rate of Tailored Triple Therapy by Adding Lactobacillus delbrueckii and Streptococcus thermophilus in Northeast Region of Thailand: A Prospective Randomized Controlled Clinical Trial

1Department of Surgery, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
2Suranaree University of Technology Hospital, Nakhon Ratchasima, Thailand
3Pathological Unit, Institute of Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
4School of Microbiology, Institute of Science, Suranaree University of Technology, Thailand
5Family Medicine and Community Medicine, Suranaree University of Technology, Nakhon Ratchasima, Thailand
6Parasite Research Unit, Suranaree University of Technology, Nakhon Ratchasima, Thailand
7Faculty of Public Health, Vongchavalitkul University, Nakhon Ratchasima, Thailand

Received 23 February 2015; Revised 23 May 2015; Accepted 26 May 2015

Academic Editor: Dimitris S. Ladas

Copyright © 2015 Taweesak Tongtawee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aim. To evaluate the effect of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus to Helicobacter pylori eradication in different periods of therapeutic protocol. Methods. Infected patients were randomized to one-week tailored triple therapy (esomeprazole 20 mg bid, clarithromycin 500 mg bid/metronidazole 400 mg tid if clarithromycin resistant, and amoxicillin 1000 mg bid) with placebo (group 1, ); one week of pretreatment with probiotics (group 2, ); and one week of pretreatment with probiotic followed by one week of the same probiotics after treatment (group 3, ). Result. PP analysis involved 292 patients, 98 in group 1, 97 in group 2, and 97 in group 3. Successful eradication was observed in 229 patients; by PP analysis, the eradication rates were significantly higher (, 95% CI; 0.71–0.97) in group 2 and group 3 than group 1. ITT analysis eradication rates were significantly higher in group 2 and group 3 than group 1 ( 95% CI; 0.72–0.87), and there is no significant difference between the three groups () in terms of adverse events. Conclusion. Adding probiotics before or before and after tailored treatment can improve Helicobacter pylori eradication rates. This trial is registered with Thai Clinical Trials Registry number: TCTR20141209001.