|
| Author | Complete response | Incomplete response | No response |
|
| Tumor response grading systems that incorporate nodal response and primary site |
| Meredith et al. [23] | Complete response: absence of histological evidence of neoplasia, gross tumor, or individual cells in the resected esophageal specimen by light microscopy but not immunohistochemical stains | Partial response: change in T or N stage from preoperative EUS or greater than 50% reduction in size of tumor compared pre- and postoperatively | No response: no change in tumor stage compared to preoperative EUS stage and postoperative pathology stage |
| Donahue et al. [21] | Complete response: microscopic absence of any viable tumor | Near-complete: microscopic focus of viable tumor cells in an otherwise necrotic specimen with no tumor remaining in resected lymph nodes | No response: macroscopic residual viable tumor at primary site and/or positive lymph nodes |
| Kim et al. [24] | No residual tumor | Residual tumor <1 cm in greatest dimension and limited to mucosa or submucosa with no nodal involvement or primary and microscopic neoplastic cells in a single regional node | No response: all other tumors |
|
| Tumor response grading systems of response at primary site only |
| Schneider et al. [25] | 0 vital residual tumor cells at primary site | <10% vital residual tumor cells at primary site
10%–50% vital residual tumor cells at primary site | >50% vital residual tumor cells at primary site |
| Chirieac et al. [20] | Complete response: no residual cancer cells | Partial response: 1%–50% residual tumor | No response: more than 50% of tumor remains |
| Mandard et al. [22] | Grade 1: complete regression | Grade 2: isolated cell nests
Grade 3: more residual cancer cells but fibrosis still predominates
Grade 4: residual cancer | Grade 5: absence of regressive changes |
| Barbour et al. [19] | N/A | Major response: <10% residual viable tumor cells | >10% residual viable tumor cells |
| Donington et al. [26] | No vital residual tumor cells at primary site | | Any residual tumor cells at primary site |
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