|
Author, year (reference) | Randomization method | Allocation concealment | Blinding | Baseline imbalance | Lost to follow-up | Source of funding |
|
Corney et al., 1991 [22] | NR | Unclear | NR | No significant differences | 2.38% | NR |
|
Greene and Blanchard, 1994 [25] | NR | NR | NR | Matched subjects (GI symptoms, axis I psychiatric diagnosis, sex, duration of IBS, and age) | 7.14% | NFP |
|
Fernandez et al., 1998 [24] | NR | NR | NR | No significant difference | 29.54% | NFP |
|
Vollmer and Blanchard, 1998 [36] | NR | NR | NR | Matched subjects (DSM-IV axis I psychiatric diagnosis, IBS subtypes, age, and duration of IBS symptoms) | NR | NFP |
|
Heymann-Mnnikes et al., 2000 [26] | Unclear | Unclear | NR | NR | 7.7% | NFP |
|
Boyce et al., 2003 [20] | Adequate Random number generator | Sealed opaque envelopes | RCC provider and data collector | Participants were similar | 50.48% | NFP |
|
Creed et al., 2003; Hyphantis et al., 2009 [15, 27] | Adequate Computer-generated random numbers Stratified by hospital and by pain severity | Unclear | Assessors | No difference in demographic or diagnostic variables | 13.62% | NFP |
|
Tkachuk et al., 2003 [35] | NR | NR | NR | Matched subjects (DSM axis I disorder, IBS subtype, IBS symptom duration, age, and gender) | NR | NFP |
|
McCrone et al., 2008; Kennedy et al., 2005;Kennedy et al., 2006 [17, 28, 29] | Adequate Random number tables | Unclear | NR | No significant difference | 11.41% | NFP |
|
Blanchard et al., 2007;Lackner et al., 2007 [19, 32] | Unclear | Not reported | Not reported | No between-group differences at baseline | 10.48% | NFP |
|
Lackner et al., 2010;Lackner et al., 2008 [31, 33] | Adequate Computer-generated random numbers | Unclear | NR | NR | 16% | NFP |
|
Chilcot and Moss-Morris, 2013;Moss-Morris et al., 2010 [21, 34] | Adequate Computer-generated random numbers | Sealed opaque envelops | Assessors | Intervention group (CBT-TAU) reported higher HADS anxiety scale | 1.56% | NFP |
|
Craske et al., 2011; Wolitzky-Taylor et al., 2012 [23, 37] | Adequate Random number generator | Opaque envelopes | Assessors | No statistically significant difference | 44.54% | NFP |
|
Gaylord et al., 2011 [12] | Adequate Computer-generated random numbers | NR | Patients, data collectors, and managers | No statistically significant difference | 12% | NFP |
|
Labus et al., 2013 [30] | Inadequate Quasi-randomized | No | No | Intervention group (psychoeducation group) reported lower GI symptom severity score and higher HADS anxiety score and level of education | NR | Includes FPO GlaxoSmithKline |
|