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Gastroenterology Research and Practice
Volume 2015, Article ID 580254, 8 pages
http://dx.doi.org/10.1155/2015/580254
Research Article

The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures

1Department of Gastroenterology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, Turkey
2Department of Pathology, Turkiye Yuksek Ihtisas Education and Research Hospital, Kiziliay Street No. 4, Sihhiye, 06100 Ankara, Turkey

Received 19 January 2015; Accepted 18 March 2015

Academic Editor: Michel Kahaleh

Copyright © 2015 Ufuk Barış Kuzu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. E. Ettinghausen, D. J. Schwartzentruber, and W. F. Sindelar, “Evolving strategies for the treatment of adenocarcinoma of the pancreas: a review,” Journal of Clinical Gastroenterology, vol. 21, no. 1, pp. 48–60, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. C. R. Thomas, H. V. Ngheim, and C. A. Pelligrini, “Pancreatic cancer diagnosis and therapy,” in Cancer of the Pancreas, H. G. Beger, M. Buchler, and M. H. Schoenberg, Eds., pp. 419–434, 1996. View at Google Scholar
  3. P. J. Thuluvath, R. Rai, A. C. Venbrux, and C. J. Yeo, “Cholangiocarcinoma: a review,” Gastroenterologist, vol. 5, no. 4, pp. 306–315, 1997. View at Google Scholar · View at Scopus
  4. N. Bourgeois, F. Dunham, A. Verhest, and M. Cremer, “Endoscopic biopsies of the papilla of Vater at the time of endoscopic sphincterotomy: Difficulties in interpretation,” Gastrointestinal Endoscopy, vol. 30, no. 3, pp. 163–166, 1984. View at Publisher · View at Google Scholar · View at Scopus
  5. K. E. Volmar, R. T. Vollmer, M. J. Routbort, and A. J. Creager, “Pancreatic and bile duct brushing cytology in 1000 cases: review of findings and comparison of preparation methods,” Cancer Cytopathology, vol. 108, no. 4, pp. 231–238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. P. G. Foutch, “Diagnosis of cancer by cytologic methods performed during ERCP,” Gastrointestinal Endoscopy, vol. 40, no. 2, part 1, pp. 249–252, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Kurzawinski, A. Deery, and B. R. Davidson, “Diagnostic value of cytology for biliary stricture,” British Journal of Surgery, vol. 80, no. 4, pp. 414–421, 1993. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Kurzawinski, A. Deery, J. Dooley, R. Dick, K. Hobbs, and B. Davidson, “A prospective controlled study comparing brush and bile exfoliative cytology for diagnosing bile duct strictures,” Gut, vol. 33, no. 12, pp. 1675–1677, 1992. View at Publisher · View at Google Scholar · View at Scopus
  9. M. de Bellis, S. Sherman, E. L. Fogel et al., “Tissue sampling at ERCP in suspected malignant biliary strictures (Part 1),” Gastrointestinal Endoscopy, vol. 56, no. 4, pp. 552–561, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A. L. Warshaw, “Implications of peritoneal cytology for staging of early pancreatic cancer,” The American Journal of Surgery, vol. 161, no. 1, pp. 26–30, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. M. De Bellis, S. Sherman, E. L. Fogel et al., “Tissue sampling at ERCP in suspected malignant biliary strictures (Part 2),” Gastrointestinal Endoscopy, vol. 56, no. 5, pp. 720–730, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Barkun, J. Liu, S. Carpenter et al., “Update on endoscopic tissue sampling devices,” Gastrointestinal Endoscopy, vol. 63, no. 6, pp. 741–745, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. L. J. Layfield, T. D. Wax, J. G. Lee, and P. B. Cotton, “Accuracy and morphologic aspects of pancreatic and biliary duct brushings,” Acta Cytologica, vol. 39, no. 1, pp. 11–18, 1995. View at Google Scholar · View at Scopus
  14. S. Eiholm, P. Thielsen, and H. Kromann-Andersen, “Endoscopic brush cytology from the biliary duct system is still valuable,” Danish Medical Journal, vol. 60, no. 7, Article ID A4656, 2013. View at Google Scholar
  15. M. Osnes, A. Serck Hanssen, and J. Myren, “Endoscopic retrograde brush cytology (ERBC) of the biliary and pancreatic ducts,” Scandinavian Journal of Gastroenterology, vol. 10, no. 8, pp. 829–831, 1975. View at Google Scholar · View at Scopus
  16. C. J. R. Stewart and G. M. Burke, “Value of p53 immunostaining in pancreatico-biliary brush cytology specimens,” Diagnostic Cytopathology, vol. 23, no. 5, pp. 308–313, 2000. View at Publisher · View at Google Scholar
  17. L. A. Desa, A. B. Akosa, S. Lazzara, P. Domizio, T. Krausz, and I. S. Bejamin, “Cytodiagnosis in the management of extrahepatic biliary stricture,” Gut, vol. 32, no. 10, pp. 1188–1191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  18. R. H. Bardales, M. W. Stanley, D. D. Simpson et al., “Diagnostic value of brush cytology in the diagnosis of duodenal, biliary, and ampullary neoplasms,” American Journal of Clinical Pathology, vol. 109, no. 5, pp. 540–548, 1998. View at Google Scholar · View at Scopus
  19. R. T. López-Jurado, G. C. Acosta, M. A. Pintos, G. R. Caravaca, J. L. L. Navarro, and C. F. Rodríguez, “Diagnostic yield of brush cytology for biliary stenosis during ERCP,” Revista Espanola de Enfermedades Digestivas, vol. 101, no. 6, pp. 385–394, 2009. View at Google Scholar · View at Scopus
  20. C. J. R. Stewart, P. R. Mills, R. Carter et al., “Brush cytology in the assessment of pancreatico-biliary strictures: a review of 406 cases,” Journal of Clinical Pathology, vol. 54, no. 6, pp. 449–455, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. P. D. J. Sturm, E. A. J. Rauws, R. H. Hruban et al., “Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis,” Clinical Cancer Research, vol. 5, no. 3, pp. 629–635, 1999. View at Google Scholar · View at Scopus
  22. N. Mahmoudi, R. Enns, J. Amar, J. AlAli, E. Lam, and J. Telford, “Biliary brush cytology: factors associated with positive yields on biliary brush cytology,” World Journal of Gastroenterology, vol. 14, no. 4, pp. 569–573, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. G. Kocjan and A. N. Smith, “Bile duct brushings cytology: potential pitfalls in diagnosis,” Diagnostic Cytopathology, vol. 16, no. 4, pp. 358–363, 1997. View at Publisher · View at Google Scholar
  24. R. Logrono, D. F. Kurtycz, C. P. Molina, V. A. Trivedi, J. Y. Wong, and K. P. Block, “Analysis of false-negative diagnoses on endoscopic brush cytology of biliary and pancreatic duct strictures: The experience at 2 university hospitals,” Archives of Pathology & Laboratory Medicine, vol. 124, no. 3, pp. 387–392, 2000. View at Google Scholar · View at Scopus
  25. T. Ponchon, P. Gagnon, F. Berger et al., “Value of endobiliary brush cytology and biopsies for the diagnosis of malignant bile duct stenosis: results of a prospective study,” Gastrointestinal Endoscopy, vol. 42, no. 6, pp. 565–572, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. J. G. Lee, J. W. Leung, J. Baillie, L. J. Layfield, and P. B. Cotton, “Benign, dysplastic, or malignant—making sense of endoscopic bile duct brush cytology: results in 149 consecutive patients,” The American Journal of Gastroenterology, vol. 90, no. 5, pp. 722–726, 1995. View at Google Scholar · View at Scopus
  27. M. A. Parsi, F. Deepinder, R. Lopez, T. Stevens, M. Dodig, and G. Zuccaro, “Factors affecting the yield of brush cytology for the diagnosis of pancreatic and biliary cancers,” Pancreas, vol. 40, no. 1, pp. 52–54, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. I. Soyuer, A. Taşdemir, Ş. Gürsoy, A. Yurci, E. Mavili, and N. Özcan, “Endoscopic biliary tract brush cytology in 54 cases,” Turkish Journal of Medical Sciences, vol. 40, no. 5, pp. 807–812, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Macken, M. Drijkoningen, E. van Aken, and W. van Steenbergen, “Brush cytology of ductal strictures during ERCP,” Acta Gastro-Enterologica Belgica, vol. 63, no. 3, pp. 254–259, 2000. View at Google Scholar · View at Scopus
  30. M. M. V. C. Urbano, A. Rosa, D. Gomes, E. Camacho, C. A. Calhau, and M. Leitão, “Team approach to ERCP-directed single-brush cytology for the diagnosis of malignancy,” Revista Española de Enfermedades Digestivas, vol. 100, no. 8, pp. 462–465, 2008. View at Google Scholar · View at Scopus
  31. N. Kawada, H. Uehara, K. Katayama et al., “Combined brush cytology and stent placement in a single session for presumed malignant biliary stricture,” Journal of Gastroenterology and Hepatology, vol. 26, no. 8, pp. 1247–1251, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. M. De Bellis, E. L. Fogel, S. Sherman et al., “Influence of stricture dilation and repeat brushing on the cancer detection rate of brush cytology in the evaluation of malignant biliary obstruction,” Gastrointestinal Endoscopy, vol. 58, no. 2, pp. 176–182, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Glasbrenner, M. Ardan, W. Boeck, G. Preclik, P. Möller, and G. Adler, “Prospective evaluation of brush cytology of biliary strictures during endoscopic retrograde cholangiopancreatography,” Endoscopy, vol. 31, no. 9, pp. 712–717, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. D. E. McGuire, R. P. Venu, R. D. Brown, K. P. Etzkorn, W. R. Glaws, and A. Abu-Hammour, “Brush cytology for pancreatic carcinoma: an analysis of factors influencing results,” Gastrointestinal Endoscopy, vol. 44, no. 3, pp. 300–304, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Rupp, C. M. Hawthorne, and H. Ehya, “Brushing cytology in biliary tract obstruction,” Acta Cytologica, vol. 34, no. 2, pp. 221–226, 1990. View at Google Scholar · View at Scopus
  36. M. S. Vadmal, S. Byrne-Semmelmeier, T. F. Smilari, and S. I. Hajdu, “Biliary tract brush cytology,” Acta Cytologica, vol. 44, no. 4, pp. 533–538, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. R. J. Farrell, A. K. Jain, S. L. Brandwein, H. Wang, R. Chuttani, and D. K. Pleskow, “The combination of stricture dilation, endoscopic needle aspiration, and biliary brushings significantly improves diagnostic yield from malignant bile duct strictures,” Gastrointestinal Endoscopy, vol. 54, no. 5, pp. 587–594, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. K. M. Mohandas, V. S. Swaroop, S. U. Gullar, U. R. Dave, P. Jagannath, and L. J. DeSouza, “Diagnosis of malignant obstructive jaundice by bile cytology: results improved by dilating the bile duct strictures,” Gastrointestinal Endoscopy, vol. 40, no. 2, part 1, pp. 150–154, 1994. View at Publisher · View at Google Scholar · View at Scopus
  39. V. K. Parasher and K. Huibregtse, “Endoscopic retrograde wire-guided cytology of malignant biliary strictures using a novel scraping brush,” Gastrointestinal Endoscopy, vol. 48, no. 3, pp. 288–290, 1998. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Morris-Stiff, M. Teli, N. Jardine, and M. C. A. Puntis, “CA19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease,” Hepatobiliary and Pancreatic Diseases International, vol. 8, no. 6, pp. 620–626, 2009. View at Google Scholar · View at Scopus
  41. Y. G. Li and N. Zhang, “Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma,” Digestive and Liver Disease, vol. 41, no. 8, pp. 605–608, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. K. H. Katsanos, M. Kitsanou, D. K. Christodoulou, and E. V. Tsianos, “High CA 19-9 levels in benign biliary tract diseases: report of four cases and review of the literature,” European Journal of Internal Medicine, vol. 13, no. 2, pp. 132–135, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Ćwik, G. Wallner, T. Skoczylas, A. Ciechański, and K. Zinkiewicz, “Cancer antigens 19-9 and 125 in the differential diagnosis of pancreatic mass lesions,” Archives of Surgery, vol. 141, no. 10, pp. 968–973, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. B. Lindberg, U. Arnelo, A. Bergquist et al., “Diagnosis of biliary strictures in conjunction with endoscopic retrograde cholangiopancreaticography, with special reference to patients with primary sclerosing cholangitis,” Endoscopy, vol. 34, no. 11, pp. 909–916, 2002. View at Publisher · View at Google Scholar · View at Scopus
  45. H. Cerwenka, R. Aigner, F. Quehenberger et al., “Preoperative differential diagnosis of benign and malignant pancreatic lesion: the value of pancreatic secretory trypsin inhibitor, procarboxypeptidase B, CA 19-9 and CEA,” Hepato-Gastroenterology, vol. 44, no. 16, pp. 1117–1121, 1997. View at Google Scholar · View at Scopus
  46. C. Levy, J. Lymp, P. Angulo, G. J. Gores, N. Larusso, and K. D. Lindor, “The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis,” Digestive Diseases and Sciences, vol. 50, no. 9, pp. 1734–1740, 2005. View at Publisher · View at Google Scholar · View at Scopus
  47. S. E. Kabawat, R. C. Bast Jr., A. K. Bhan, W. R. Welch, R. C. Knapp, and R. B. Colvin, “Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125,” International Journal of Gynecological Pathology, vol. 2, no. 3, pp. 275–285, 1983. View at Publisher · View at Google Scholar · View at Scopus
  48. C.-Y. Chen, S.-C. Shiesh, H.-C. Tsao, and X.-Z. Lin, “The assessment of biliary CA 125, CA 19-9 and CEA in diagnosing cholangiocarcinoma—the influence of sampling time and hepatolithiasis,” Hepato-Gastroenterology, vol. 49, no. 45, pp. 616–620, 2002. View at Google Scholar · View at Scopus
  49. C. Haglund, “Tumour marker antigen CA125 in pancreatic cancer: a comparison with CA19-9 and CEA,” British Journal of Cancer, vol. 54, no. 6, pp. 897–901, 1986. View at Publisher · View at Google Scholar · View at Scopus
  50. N. Duraker, S. Hot, Y. Polat, A. Höbek, N. Gençler, and N. Urhan, “CEA, CA 19-9, and CA 125 in the differential diagnosis of benign and malignant pancreatic diseases with or without jaundice,” Journal of Surgical Oncology, vol. 95, no. 2, pp. 142–147, 2007. View at Publisher · View at Google Scholar · View at Scopus