The Diagnostic Value of Brush Cytology Alone and in Combination with Tumor Markers in Pancreaticobiliary Strictures
Table 1
Baseline characteristics.
Clinical characteristics
Value
Patient
273
Age (year)
61.2 ± 13.8
Male/female
127 (46.5)/(53.5) 146
Clinical diagnosis
Malignant
141 (51.6%)
Cholangiocarcinoma
59 (41.9%)
Pancreatic cancer
55 (39.1%)
Periampullary tumor
7 (5.0%)
Gallbladder cancer
5 (3.5%)
Intraductal papillary mucinous neoplasm
4 (2.8%)
Hepatocellular carcinoma
3 (2.1%)
Neuroendocrine tumor
2 (1.4%)
Metastasis*
6 (4.2%)
Benign
132 (48.4%)
Common bile duct stone
57 (43.2%)
Postoperative stricture
25 (18.9%)
Primary slerosing cholangitis
22 (16.7%)
Chronic pancreatitis
21 (15.9%)
Other**
7 (5.3%)
Lesion location (malignant/benign)
Intrahepatic
4 (2.8%)/13 (9.8%)
Perihilar region
49 (34.8%)/29 (21.9%)
Common bile duct
84 (59.6%)/82 (62.2%)
Pancreas
4 (2.8%)/8 (6.1%)
Dilatation +/−
46 (16.8%)/227 (83.2%)
CT/USG scan findings
Could not be obtained
56 (20.5%)
Mass not seen
144 (52.8%)
Mass <10 mm
2 (0.7%)
10–30 mm
23 (8.4%)
Mass >30 mm
48 (17.6%)
Laboratory findings
Glucose (mg/dL)
104 ± 61.2
ALT (U/L)
112 (7–4660)
AST (U/L)
87.2 (10–2225)
GGT (U/L)
239 (9–2465)
ALP (U/L)
282 (2–3217)
Total bilirubin (mg/dL)
5.7 ± 6.4
Tumor markers
AFP (U/mL)
1.8 (0.1–1852)
CA-19.9 (U/mL)
64 (1–2085)
CA125 (ng/mL)
20.5 (0.1–1000)
CEA (ng/mL)
2.5 (1–577)
Values are presented as number (%), mean ± SD or median (range). 3 colon cancer, 1 breast cancer, 1 ovary cancer, and 1 lung cancer. 2 Mirizzi syndrome, 2 choledochal cysts, 2 Oddi Sphincter spasm type 1, and 2, Eisonophilic cholangitis.
