Clinical Study

Narrow-Band Imaging Magnifying Endoscopy versus Lugol Chromoendoscopy with Pink-Color Sign Assessment in the Diagnosis of Superficial Esophageal Squamous Neoplasms: A Randomised Noninferiority Trial

Table 2

Patient demographics and SESCC lesion characteristics.

NBI-ME ( = 147)LCE-PS ( = 147)

Patient demographics
 Age, years; median (range)67 (39–86)66 (35–85)NS
 Men; 130131NS
 History of HNSCC/ESCC;
  Number of patients; 85/7488/69NS
 Drinking habit
  Number of drinkers; 134129NS
  Drinking duration, years; median (range)40 (10–68)40 (1–60)NS
  Number of flushers; 102100NS
 Smoking habit
  Number of smokers; 129128NS
  Smoking, years; median (range) 35 (3–70)37 (1–59)NS
 Number of patients with grade D LVL pattern; 33 (22%)29 (20%)NS
 Final histology
  Number of patients with nonneoplasia/LGIN/SESCC80/22/4587/19/41NS
SESCC lesion characteristics
 Number of SESCC lesions5462NS
 Diameter, mm; median (range)29 (4–100)25 (6–70)NS
 Macroscopic tumor type (0-I/IIa, IIb, and IIc/III)5/48 (88%)/13/59 (95%)/0NS
 Histology, HGIN or T1a/T1b; /49 (91%)/557 (88%)/5NS
 Treatment
  ER/SR/CRT/others32/11/5/640/13/1/8NS

NBI-ME: narrow-band imaging magnifying endoscopy; LCE-PS: Lugol chromoendoscopy with pink-color sign assessment; LVL: Lugol voiding lesion; LGIN: low-grade intraepithelial neoplasia; HGIN: high-grade intraepithelial neoplasia; SESCC: superficial esophageal squamous cell carcinoma. ER: endoscopic resection; SR: surgical resection; CRT: chemoradiotherapy; Mann-Whitney test; -test; NS: not significant.