Narrow-Band Imaging Magnifying Endoscopy versus Lugol Chromoendoscopy with Pink-Color Sign Assessment in the Diagnosis of Superficial Esophageal Squamous Neoplasms: A Randomised Noninferiority Trial

Table 5

Clinicopathological characteristics of misdiagnosed lesions.

	False-negative SESCCs		False-positive non-SESCC lesions
	NBI-ME	LCE-PS	NBI-ME	LCE-PS
Number of lesions	19	12	15	16
Diameter, mm; median (range)	12 (4–35)	10 (6–25)	12 (6–30)	10 (6–40)
Macroscopic type,; (0-I/IIa, IIb, IIc/III)	0/0, 17, 2/0	0/2, 10, 0/0	0/1, 12, 2/0	0/0, 13, 3/0
Histology; from biopsy;	HGIN: 8; Invasive SCC: 11	HGIN: 4; Invasive SCC: 8	LGIN: 13; Inflammation: 1; Normal epithelium: 1	LGIN: 10; Inflammation: 3; Necrosis: 1; Normal epithelium: 2
Invasion depth of tumors in resected cases (by ER or SR):	T1a-LPM: 5; T1a-MM: 1; T1b-SM1: 1	T1a-LPM: 5	None	None
Lugol voiding pattern; , A/B/C/D	0/0/2/17	0/1/3/8	0/2/4/9	0/4/5/7
(Proportion of grade D)	(89%)	(67%)	(60%)	(44%)

SESCC: superficial esophageal squamous cell carcinoma including HGIN; NBI-ME: narrow-band imaging magnifying endoscopy; LCE-PS: Lugol chromoendoscopy with pink-color sign assessment; HGIN: high-grade intraepithelial neoplasia; LGIN: low-grade intraepithelial neoplasia; ER: endoscopic resection; SR: surgical resection; , : not significant (Pearson’s test).