Interval Cancers in a Population-Based Screening Program for Colorectal Cancer in Catalonia, Spain

Table 4

Factors associated with clinically diagnosed CRC among individuals who ever participated in the screening program for CRC (≤30 months versus >30 months since their last screening).

	Interval CRC ≤30 months		Clinically diagnosed CRC >30 months
	ORa	95% CI	ORa	95% CI
Gender
Men	1		1
Women	1.02	(0.44–2.33)	1.94	(0.69–5.43)
Age at diagnosis^*	1.03	(0.96–1.11)	1.38	(1.24–1.53)
Number of screens	1.24	(0.85–1.81)	0.55	(0.32–0.94)
Tumor site
Distal	1		1
Proximal	1.32	(0.51–3.39)	3.73	(1.21–11.51)
Rectum	3.66	(1.51–8.88)	3.48	(1.02–11.87)
Tumor stage
I	1		1
II	2.63	(0.86–8.04)	2.21	(0.61–8.07)
III	3.45	(1.39–8.30)	1.66	(0.51–5.43)
IV	2.80	(0.73–10.76)	4.86	(1.02–23.24)

OR_a adjusted odds ratios derived from multivariate logistic regression models. Analysis was restricted to those individuals with a negative result in their last screening that have been diagnosed with CRC later on and those who were diagnosed during the screening process. ^*Age at diagnosis was considered as a continuous variable; the age range was 50–73 years for individuals with a CRC diagnosed within 30 months after their screening and 55–80 years for individuals who ever participated in the screening program and were diagnosed with CRC.