Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015, Article ID 672460, 5 pages
Research Article

Recurrent Posterior Strokes in Inflammatory Bowel Disease Patients

1Department of Neurology, University of Iowa, Iowa City, USA
2Department of Gastroenterology, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
3Department of Neurology, Louisiana State University Health Sciences Center New Orleans, New Orleans, USA
4Department of Internal Medicine, Section of Gastroenterology, Tulane University School of Medicine, New Orleans, USA
5Department of Neurology, Tulane University School of Medicine, New Orleans, USA

Received 12 October 2014; Accepted 28 January 2015

Academic Editor: Mala Banerjee

Copyright © 2015 Amir Shaban et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical research on the association between IBD and stroke. Methods. We retrospectively reviewed consecutive patients with acute ischemic stroke presenting to our medical center from 7/2008 to 9/2013. Patients with a history of IBD were identified. Clinical variables were abstracted from our prospective stroke registry. Results. Over the period of five years we identified only three patients with a documented history of IBD. Each of these patients presented three times to our hospital with new strokes. Patients presented outside the window for intravenous tPA treatment on 8/9 admissions. Each one of our patients had posterior strokes on at least two separate occasions. Hypercoagulation panel showed elevated factor VIII with or without concomitant elevation of Von Willebrand factor (vWF) during almost every admission (8/9 admissions). Only one admission was associated with IBD flare. Conclusion. The association between IBD and posterior strokes is a novel finding. Factor VIII elevation may serve as a biomarker of a peristroke hypercoagulable state in patients with IBD.