Endothelial Dysfunction Correlates with Liver Fibrosis in Chronic HCV Infection
Table 1
Demographic, serological, and anthropometric parameters, systolic blood pressure, and stage of fibrosis assessed by fibroscan and APRI, in the 3 tertiles.
I tertile
II tertile
III tertile
Number of pts.
15
15
15
M/F
6/9
10/5
8/7
0.32*
Age
59.7 (11.8)
61.5 (9.4)
65.6 (8.1)
0.28
BMI
25.1 (3.7)
26.5 (2.1)
27.1 (3.5)
0.20
Waist circumference (cm)
87.1 (13.4)
90.6 (10.3)
92.8 (9.1)
0.35
Total cholesterol (mg/dL)
171.5 (23.4)
165.2 (20.7)
150.8 (31.6)
0.09
Triglycerides (mg/dL)
75.3 (23.7)
97.7 (59.8)
86.9 (47.5)
0.44
ALT†
33.2 (22.4)
72.4 (86.0)
68.8 (56.7)
0.17
AST†
36.1 (14.3)
55.5 (34.9)
69 (40.2)
0.02‡
HCV-RNA genotype 1
66.7%
73.3%
73.3%
0.89*
Quantitative HCV-RNA (UI/mL)
3,718,195 (7,587,287)
1,300,529 (2,267,567)
2,511,572 (5,442,431)
0.51
Systolic blood pressure (mmHg)
126.9 (10.5)
129.0 (10.2)
129.6 (11.4)
0.81
APRI
0.4 (0.1)
0.7 (0.4)
1.5 (1.0)
<0.001
Fibroscan (Kpa)
4.9 (0.8)
8.6 (1.4)
27.2 (12.1)
<0.001
The values reported in the table represent the mean (SD) or the percentages obtained in all patients. *By Chi-Squared test. †Normal value: 40 UI/L. ‡ANOVA demonstrated a significant difference among the 3 groups. I tertiles ≠ II tertiles; I tertiles ≠ III tertiles by Tukey test. ANOVA demonstrated a significant difference among the 3 groups. I tertiles ≠ II tertiles ≠ III tertiles by Tukey test.
