Review Article
Hepatocellular Carcinoma in Liver Cirrhosis: Surgical Resection versus Transarterial Chemoembolization—A Meta-Analysis
Table 1
Demographics and specific results of all studies included in this meta-analysis.
| | Reference | Year | Inclusion period | Country | Number of patients
(HR/TACE) | M/F
(HR/TACE) | Mean age (years) | Mean AFP (ng/mL) | Child-Pugh
A
B
C | Tumor size (cm) | Bilirubin total (mg/dL) | Albumin (g/dL) | Tumor number
(HR/TACE) |
| | Choi et al. [13] | 2013 | 2003–2008 | South Korea | 36/107 | 34/2
86/21 | 54.3 ± 8.6
61.2 ± 9.3 | — | — | ≤3 19/17
≥3 29/78 | — | 4.05 ± 0.5
3.93 ± 0.48 | 2 : 30/2 : 90
3 : 6/3 : 17 | | Ho et al. [14] | 2009 | 1981–2000 | Taiwan | 294/367 | 240/54
290/77 | 57.0 ± 11.8
60.1 ± 12.3 | 8216 ± 55270
13464 ± 65879 | 229/234
13/49
0/9 | 5.0 ± 3.5/5.3 ± 3.5 | 1.2 ± 1.9
1.3 ± 1.4 | 3.8 ± 0.5
3.5 ± 0.5 | — | | Hsu et al. [15] |
2012 | 2001–2007 | Taiwan | 112/73 | 76/39
— | 60.3 ± 11.7
61.9 ± 11.7 | ≥200 30/13
≤200 82/60 | — | 2.48 ± 0.69
2.34 ± 0.74 | 0.81 ± 0.33
0.91 ± 0.45 | 3.98 ± 0.45
3.87 ± 0.41 | S: 41/S: 83
M: 32/M: 29 | | Lee et al. [16] | 2002 | 1993–1994 | Korea | 91/91 | 76/15
79/12 | 50 ± 10
65 ± 10 | <400 8/60
≥400 33/31 | — | — | — | — | — | | Lin et al. [17] | 2010 | 2001–2007 | Taiwan | 93/73 | 75/18
53/25 | 59 ± 15.6
62 ± 12.9 | ≥400 45/35
<400 48/43 | — | 8.0 ± 3.3
7.7 ± 4.4 | 1.8 ± 1.2
1.3 ± 1.3 | 3.8 ± 0.5
3.3 ± 0.5 | S: 49/S: 22
M: 44/M: 56 | | Luo et al. [18] | 2011 | 2004–2006 | China | 85/83 | 70/15
79/4 | 47.5 ± 12.8
50.9 ± 11.2 | 238.5 (0–121000)
306.6 (0.6–121000) | 60/71
4/1 | 8.7 ± 3.5 (5–20)
7.8 ± 2.5 (5–15) | 15.8 ± 6.9
17.1 ± 7.4 | 4.05 ± 0.36
4.16 ± 0.40 | 2 : 35/2 : 32
3 : 20/3 : 11
>4 : 30/>4 : 40 | | Peng et al. [19] | 2012 | 2002–2007 | China | 201/402 | 187/14
374/28 | 55 (25–75)
55 (23–75) | 562.3
598.5 | 197/389
4/13 | ≤5 76/178
≥5 125/224 | 1.29
1.25 | 3.68
3.63 | 1 : 95/1 : 132
>1.106/>1 : 270 | | Sasaki et al. [20] |
1998 | 1980–1994 | Japan | 384/534 | 3.7
4.7 | 60 ± 8.4
62 ± 7.4 | — | — | 3.9 ± 3.3
5.4 ± 3.7 | 0.8 ± 0.4
1.1 ± 0.5 | 3.7 ± 0.4
3.6 ± 0.5 | 2-3 : 26/2-3 : 33
<4 : 0/<4 : 2 | | Sotiropoulos et al. [21] |
2009 | | | 61/64 | | | | | | | | | | Utsunomiya et al. [22] | 2014 | 2000–2005 | Japan | 2872/1437 | 2332/540
1124/313 | 67 (50, 79)
69 (53, 83) | 3491 (15, 16368)
3177 (15, 13605) | 2679/1068
193/369 | 5.8 (1.8, 14)
5.0 (1.4, 13) | 0.8 (0.4, 1.5)
1.1 (0.4, 2.3) | 4.0 (3.2, 4.7)
3.7 (2.8, 4.5) | 1 : 2193/1 : 316
2 : 323/2 : 85
>3 : 126/>3 : 28 | | Zhong et al. 1 [8] |
2014 | 2000–2007 | China | 908/351 | 824/84
326/25 | 44 (17–78)
53 (19–82) | ≥400 434/158
≤400 474/193 | — | 8 (4–20)/10 (4–20) | 1.3 (0.5–4.0)
1.7 (0.3–22) | 3.9 (2.8–4.7)
3.9 (2.2–5.1) | <3845/<3 : 319
>3 : 63/>3 : 32 | | Zhong et al. 2 [23] | 2013 | 2000–2007 | China | 257/135 | 233/24
127/8 | 46.8 ± 12.0
48.7 ± 12.5 | ≥400 143/66
≤400 114/69 | — | 8.9 ± 3.0
8.8 ± 2.5 | 14.5 ± 5.3
15.1 ± 8.5 | — | S: 199/S: 104
M: 85/M: 31 |
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