Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015, Article ID 717431, 10 pages
http://dx.doi.org/10.1155/2015/717431
Research Article

Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease

1Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato, Tokyo 105-8461, Japan
2Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan
3Clinical Data & Biostatistics Department, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, Japan
4Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Japan

Received 29 September 2014; Revised 7 February 2015; Accepted 9 February 2015

Academic Editor: Paolo Gionchetti

Copyright © 2015 Tomonori Sugita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Pellicoro and K. N. Faber, “Review article: the function and regulation of proteins involved in bile salt biosynthesis and transport,” Alimentary Pharmacology & Therapeutics, vol. 26, supplement 2, pp. 149–160, 2007. View at Publisher · View at Google Scholar
  2. J. M. Ridlon, D.-J. Kang, and P. B. Hylemon, “Bile salt biotransformations by human intestinal bacteria,” Journal of Lipid Research, vol. 47, no. 2, pp. 241–259, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. C. N. Falany, M. R. Johnson, S. Barnes, and R. B. Diasio, “Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N- acyltransferase,” The Journal of Biological Chemistry, vol. 269, no. 30, pp. 19375–19379, 1994. View at Google Scholar · View at Scopus
  4. I. Burkard, A. von Eckardstein, and K. M. Rentsch, “Differentiated quantification of human bile acids in serum by high-performance liquid chromatography-tandem mass spectrometry,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 826, no. 1-2, pp. 147–159, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. S. E. Lucangioli, G. Castaño, M. D. Contin, and V. P. Tripodi, “Lithocholic acid as a biomarker of intrahepatic cholestasis of pregnancy during ursodeoxycholic acid treatment,” Annals of Clinical Biochemistry, vol. 46, no. 1, pp. 44–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Ye, S. Liu, M. Wang, Y. Shao, and M. Ding, “High-performance liquid chromatography-tandem mass spectrometry for the analysis of bile acid profiles in serum of women with intrahepatic cholestasis of pregnancy,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 860, no. 1, pp. 10–17, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Joshi, A. James, A. Quaglia, R. H. Westbrook, and M. A. Heneghan, “Liver disease in pregnancy,” The Lancet, vol. 375, no. 9714, pp. 594–605, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. P. R. Bathena, S. Mukherjee, M. Olivera, and Y. Alnouti, “The profile of bile acids and their sulfate metabolites in human urine and serum,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 942-943, pp. 53–62, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Xiang, Y. Han, M. Neuvonen, J. Laitila, P. J. Neuvonen, and M. Niemi, “High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 878, no. 1, pp. 51–60, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. I. Makino, H. Hashimoto, K. Shinozaki, K. Yoshino, and S. Nakagawa, “Sulfated and nonsulfated bile acids in urine, serum, and bile of patients with hepatobiliary diseases,” Gastroenterology, vol. 68, no. 3, pp. 545–553, 1975. View at Google Scholar · View at Scopus
  11. J. Trottier, A. Białek, P. Caron et al., “Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: a Pilot Study,” Digestive and Liver Disease, vol. 44, no. 4, pp. 303–310, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Xie, W. Zhong, H. Li et al., “Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption,” The FASEB Journal, vol. 27, no. 9, pp. 3583–3593, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Purohit, J. C. Bode, C. Bode et al., “Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium,” Alcohol, vol. 42, no. 5, pp. 349–361, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Corrao, P. Ferrari, A. Zambon, and P. Torchio, “Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries,” Journal of Studies on Alcohol, vol. 58, no. 5, pp. 486–494, 1997. View at Google Scholar · View at Scopus
  15. C. J. Sinal, M. Tohkin, M. Miyata, J. M. Ward, G. Lambert, and F. J. Gonzalez, “Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis,” Cell, vol. 102, no. 6, pp. 731–744, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Duran-Sandoval, B. Cariou, F. Percevault et al., “The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition,” The Journal of Biological Chemistry, vol. 280, no. 33, pp. 29971–29979, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Ma, P. K. Saha, L. Chan, and D. D. Moore, “Farnesoid X receptor is essential for normal glucose homeostasis,” Journal of Clinical Investigation, vol. 116, no. 4, pp. 1102–1109, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Cipriani, A. Mencarelli, G. Palladino, and S. Fiorucci, “FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats,” Journal of Lipid Research, vol. 51, no. 4, pp. 771–784, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Thomas, A. Gioiello, L. Noriega et al., “TGR5-mediated bile acid sensing controls glucose homeostasis,” Cell Metabolism, vol. 10, no. 3, pp. 167–177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Makishima, A. Y. Okamoto, J. J. Repa et al., “Identification of a nuclear receptor for bite acids,” Science, vol. 284, no. 5418, pp. 1362–1365, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. D. J. Parks, S. G. Blanchard, R. K. Bledsoe et al., “Bile acids: natural ligands for an orphan nuclear receptor,” Science, vol. 284, no. 5418, pp. 1365–1368, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Maruyama, Y. Miyamoto, T. Nakamura et al., “Identification of membrane-type receptor for bile acids (M-BAR),” Biochemical and Biophysical Research Communications, vol. 298, no. 5, pp. 714–719, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Kawamata, R. Fujii, M. Hosoya et al., “A G protein-coupled receptor responsive to bile acids,” The Journal of Biological Chemistry, vol. 278, no. 11, pp. 9435–9440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Watanabe, S. M. Houten, C. Mataki et al., “Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation,” Nature, vol. 439, no. 7075, pp. 484–489, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. D. Lake, P. Novak, P. Shipkova et al., “Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease,” Toxicology and Applied Pharmacology, vol. 268, no. 2, pp. 132–140, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Sugita, K. Amano, M. Nakano, N. Masubuchi, M. Sugihara, and T. Matsuura, “Analysis of the serum bile acid composition in patients with liver disease determined according to the LC-MS/MS method,” Hepatology, vol. 58, supplement, p. 151A, 2013. View at Google Scholar