KRAS and BRAF Mutation Detection: Is Immunohistochemistry a Possible Alternative to Molecular Biology in Colorectal Cancer?

Table 1

KRAS, phenotype, and genotype.

Case	Sex	Age (years)	KRAS staining	Molecular status (protein effect)
1	M	75	Positive	Mutated (G12D/G13D)
2	M	68	Positive	Mutated (G12A)
3	F	65	Positive	Mutated (G12C)
4	M	53	Negative	Mutated (G12D)
5	M	72	Negative	Mutated (G12V)
6	M	61	Negative	Mutated (G13D)
7	M	72	Negative	Mutated (G12S)
8	F	59	Negative	Mutated (G12R)
9	F	61	Negative	Mutated (G13D)
10	M	41	Negative	Mutated (G12A)
11	F	66	Negative	Mutated G12C)
12	M	69	Negative	Wild type
13	F	52	Negative	Wild type
14	M	38	Negative	Wild type
15	M	69	Negative	Wild type
16	M	68	Negative	Wild type
17	M	68	Negative	Wild type
18	M	55	Negative	Wild type
19	F	72	Negative	Wild type
20	M	59	Negative	Wild type
21	M	67	Negative	Wild type
22	M	62	Negative	Wild type
23	M	57	Negative	Wild type
24	M	79	Negative	Wild type
25	M	75	Negative	Wild type
26	M	63	Positive	Wild type
27	M	72	Positive	Wild type
28	F	58	Positive	Wild type
29	M	53	Positive	Wild type
30	F	60	Positive	Wild type
31	F	42	Positive	Wild type
32	M	67	Positive	Wild type
33	F	70	Positive	Wild type

F: female; M: male; MSI: microsatellite-instable; MSS: microsatellite-stable.