Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer

Table 1

FGFR protein expressions on immunohistochemical analysis and clinical outcomes in GC.

		Definition of positivity	Positive case %	Relation to clinicopathological factors	Relation to survival	Reference
FGFR1	222	Scoring system of intensity + extensity	29	T, N, M, stage	Worse	[19]
FGFR2	950	2+ or 3+, >50%	31	T, N, M, stage	Worse	[22]
	222	Scoring system of intensity + extensity	51	T, N, M, stage	Worse	[19]
	136	Stronger than normal epithelium	31	T, peritoneal Dissemination, diffuse type	Worse	[20]
	49	Stronger than normal epithelium	41	Stage; Undifferentiated type	Worse	[21]
FGFR3	222	Scoring system of intensity + extensity	64	NA	NA	[19]
FGFR4	222	Scoring system of intensity + extensity score	79	T, N, M, stage	Worse	[19]
	94	3+, >10%	38	NA	Worse	[23]

T: tumor depth; N: lymph-node metastasis; M: distant metastasis; NA: not assisted.