Association between JAK2 rs4495487 Polymorphism and Risk of Budd-Chiari Syndrome in China

Table 2

Association between JAK2 rs4495487 polymorphism and Budd-Chiari syndrome patients.

		rs4495487 genotype			C allele		Odds ratio (95% CI)
		CC	CT	TT	frequency		CC versus TT	CC/CT versus TT	CC versus CT/TT
Controls	310	10	96	204	0.187
Overall	280	15	82	183	0.200	0.575	1.67 (0.73–3.81)	1.02 (0.73–1.43)	1.70 (0.75–3.84)
JAK2 status
JAK2-positive	7	3	2	2	0.429	<0.01	13.60 (2.04–90.79)	2.57 (0.56–11.68)	12.00 (2.07–69.52)
JAK2-negative	273	13	80	180	0.194	0.760	1.47 (0.63–3.44)	0.99 (0.71–1.40)	1.50 (0.65–3.48)
Type of BCS
IVC	173	9	55	109	0.211	0.370	1.61 (0.64–4.08)	0.98 (0.66–1.45)	1.65 (0.66–4.13)
HV	68	2	24	42	0.206	0.613	0.97 (0.21–4.60)	1.17 (0.68–2.02)	0.91 (0.20–4.25)
Com	39	4	7	28	0.192	0.912	3.02 (0.89–10.31)	0.84 (0.41–1.73)	4.44 (1.31–15.12)

BCS: Budd-Chiari syndrome; HV: hepatic vein; IVC: inferior vena cava; Com: combined obstruction of hepatic vein and inferior vena cava.
: value for C-allele frequency comparisons.