Gastroenterology Research and Practice / 2015 / Article / Tab 3 / Research Article
Repeat Upper Gastrointestinal Endoscopy in Patients with Functional Dyspepsia: Yield, Findings, and Predictors of Positive Findings Table 3 Univariate and multivariate analyses of the clinical parameters between patients with positive and negative findings on repeat EGD (data are shown in
(%), unless specified).
Clinical parameters Univariate analysis Multivariate analysis Negative repeat EGD ( ) Positive repeat EGD ( ) Hazard ratio (95% CI) Age (years), mean ± SD 56.4 ± 11.8 58.3 ± 10.9 0.432 Gender, female 75 (65.2) 18 (58.1) 0.462 Time to repeat EGD (months), median (range) 33.5 (1–168) 36.1 (7–118) 0.421 Comorbid illnesses Diabetes 15 (13.0) 3 (9.7) 0.765 Hypertension 40 (34.8) 18 (58.1) 0.019 2.96 (1.38–6.36) 0.050 Dyslipidemia 32 (27.8) 11 (35.5) 0.406 Coronary artery disease 7 (6.1) 5 (16.1) 0.071 Kidney diseases 1 (0.9) 0 1.000 Liver diseases 0 0 1.000 Malignancies 3 (2.6) 4 (12.9) 0.037 3.65 (1.16–11.46) 0.027 Family history of GI malignancies 6 (5.2) 1 (3.2) 1.000 Smoking 8 (6.9) 5 (16.1) 0.015 3.88 (1.31–11.51) 0.015 Alcohol drinking 11 (9.5) 1 (3.2) 0.462 Use of NSAIDs or antiplatelets 23 (20.0) 11 (35.5) 0.007 4.10 (1.13–14.90) 0.032 Night pain/awakening pain 3 (2.6) 1 (3.2) 1.000 Indications of repeat EGD Dyspepsia with age ≥55 years 11 (9.5) 1 (3.2) 0.462 Dyspepsia with alarm features 24 (20.9) 6 (19.4) 0.853 Dyspepsia with failed medical therapy 56 (48.7) 18 (58.1) 0.354 Patients’ request 6 (5.2) 3 (9.7) 0.401 Others 10 (8.7) 3 (9.7) 1.000 Not specified 4 (3.5) 1 (3.2) 1.000 Alarm features Dysphagia 0 0 — Unexplained weight loss 17 (14.8) 4 (12.9) 1.000 Persistent vomiting 0 0 — Evidence of GI blood loss 7 (6.1) 1 (3.2) 1.000 Use of PPI within 8 wk 89 (77.4) 23 (74.2) 0.709 H. pylori infection6 (5.2) 3 (9.7) 0.400
EGD, esophagogastroduodenoscopy; GI, gastrointestinal; NSAIDs, non-steroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SD, standard deviation.