Gastroenterology Research and Practice / 2015 / Article / Tab 3

Research Article

Repeat Upper Gastrointestinal Endoscopy in Patients with Functional Dyspepsia: Yield, Findings, and Predictors of Positive Findings

Table 3

Univariate and multivariate analyses of the clinical parameters between patients with positive and negative findings on repeat EGD (data are shown in (%), unless specified).

Clinical parametersUnivariate analysisMultivariate analysis
Negative repeat EGD
()
Positive repeat EGD
()
Hazard ratio (95% CI)

Age (years), mean ± SD56.4 ± 11.858.3 ± 10.90.432
Gender, female 75 (65.2)18 (58.1)0.462
Time to repeat EGD (months), median (range)33.5 (1–168)36.1 (7–118)0.421
Comorbid illnesses
 Diabetes15 (13.0)3 (9.7)0.765
 Hypertension40 (34.8)18 (58.1)0.0192.96 (1.38–6.36)0.050
 Dyslipidemia32 (27.8)11 (35.5)0.406
 Coronary artery disease7 (6.1)5 (16.1)0.071
 Kidney diseases1 (0.9)01.000
 Liver diseases001.000
 Malignancies3 (2.6)4 (12.9)0.0373.65 (1.16–11.46)0.027
Family history of GI malignancies6 (5.2)1 (3.2)1.000
Smoking8 (6.9)5 (16.1)0.0153.88 (1.31–11.51)0.015
Alcohol drinking11 (9.5)1 (3.2)0.462
Use of NSAIDs or antiplatelets23 (20.0)11 (35.5)0.0074.10 (1.13–14.90)0.032
Night pain/awakening pain3 (2.6)1 (3.2)1.000
Indications of repeat EGD
 Dyspepsia with age ≥55 years11 (9.5)1 (3.2)0.462
 Dyspepsia with alarm features24 (20.9)6 (19.4)0.853
 Dyspepsia with failed medical therapy56 (48.7)18 (58.1)0.354
 Patients’ request6 (5.2)3 (9.7)0.401
 Others10 (8.7)3 (9.7)1.000
 Not specified4 (3.5)1 (3.2)1.000
Alarm features
 Dysphagia00
 Unexplained weight loss17 (14.8)4 (12.9)1.000
 Persistent vomiting00
 Evidence of GI blood loss7 (6.1)1 (3.2)1.000
Use of PPI within 8 wk89 (77.4)23 (74.2)0.709
H. pylori infection6 (5.2)3 (9.7)0.400

EGD, esophagogastroduodenoscopy; GI, gastrointestinal; NSAIDs, non-steroidal anti-inflammatory drugs; PPI, proton pump inhibitor; SD, standard deviation.

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