Research Article
The Anti-Inflammatory Activity of a Novel Fused-Cyclopentenone Phosphonate and Its Potential in the Local Treatment of Experimental Colitis
Figure 6
MPO activity (a), iNOS expression (b), TNFα (c), and IL-1β (d) tissue levels in the colons of healthy rats, untreated DNBS-induced rats, and DNBS-induced rats treated with P-5 and 5-ASA. Results are normalized to total tissue protein. (a), (c), and (d) are expressed as a fraction (in %) of the tissue biomarker levels in the DNBS-treated group. (b) is normalized to the house keeping gene, GAPDH. Shown are the mean ± S.D. values of 3–7 rats in each group. ANOVA of the effect of P-5 on MPO activity was F3,19 = 13.63 , on iNOS expression was F2,18 = 37.57 , on TNFα level was F3,22 = 9.00 , and on IL-1β level was F3,31 = 22.61 . ; ; compared with the DNBS group.
| (a) |
| (b) |
| (c) |
| (d) |