Table of Contents Author Guidelines Submit a Manuscript
Gastroenterology Research and Practice
Volume 2015 (2015), Article ID 970940, 7 pages
http://dx.doi.org/10.1155/2015/970940
Research Article

Differential Expression of Motilin Receptor in Various Parts of Gastrointestinal Tract in Dogs

1Third Clinical College of Norman Bethune Medical Division, Jilin University, Changchun, Jilin 130033, China
2Second Clinical College of Norman Bethune Medical Division, Jilin University, Changchun, Jilin 130041, China

Received 11 October 2014; Revised 12 November 2014; Accepted 17 November 2014

Academic Editor: Byung Joo Kim

Copyright © 2015 Yu He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Poitras, “Motilin is a digestive hormone in the dog,” Gastroenterology, vol. 87, no. 4, pp. 909–913, 1984. View at Google Scholar · View at Scopus
  2. P. Miller, L. Trudel, S. St-Pierre, H. Takanashi, and P. Poitras, “Neural and muscular receptors for motilin in the rabbit colon,” Peptides, vol. 21, no. 2, pp. 283–287, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. Z. Itoh, “Motilin and clinical application,” Peptides, vol. 18, no. 4, pp. 593–608, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. J. He, D. M. Irwin, R. Chen, and Y.-P. Zhang, “Stepwise loss of motilin and its specific receptor genes in rodents,” Journal of Molecular Endocrinology, vol. 44, no. 1, pp. 37–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. G. J. Sanger, J. D. Holbrook, and P. L. R. Andrews, “The translational value of rodent gastrointestinal functions: a cautionary tale,” Trends in Pharmacological Sciences, vol. 32, no. 7, pp. 402–409, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Costa, F. de Ponti, G. Gibelli, F. Crema, and L. d'Angelo, “In vivo characterization of the colonic prokinetic effect of erythromycin in the rabbit,” Pharmacology, vol. 54, no. 2, pp. 64–75, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. G. J. Sanger, S. M. Westaway, A. A. Barnes et al., “GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility,” Neurogastroenterology and Motility, vol. 21, no. 6, pp. 657–e31, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. C. E. Stevens and I. D. Hume, Comparative Physiology of the Vertebrate Digestive System, Cambridge University Press, 2nd edition, 1995.
  9. P. Miller, A. Roy, S. St-Pierre, M. Dagenais, R. Lapointe, and P. Poitras, “Motilin receptors in the human antrum,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 278, no. 1, pp. G18–G23, 2000. View at Google Scholar · View at Scopus
  10. H. Ohshiro, M. Nonaka, and K. Ichikawa, “Molecular identification and characterization of the dog motilin receptor,” Regulatory Peptides, vol. 146, no. 1–3, pp. 80–87, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. E. Takeshita, B. Matsuura, M. Dong, L. J. Miller, H. Matsui, and M. Onji, “Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract,” Journal of Gastroenterology, vol. 41, no. 3, pp. 223–230, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Itoh and T. Sekiguchi, “Interdigestive motor activity in health and disease,” Scandinavian Journal of Gastroenterology, Supplement, vol. 82, pp. 121–134, 1983. View at Google Scholar · View at Scopus
  13. K. Y. Lee, T. M. Chang, and W. Y. Chey, “Effect of rabbit antimotilin serum on myoelectric activity and plasma motilin concentration in fasting dog,” The American Journal of Physiology, vol. 245, no. 4, pp. G547–G553, 1983. View at Google Scholar · View at Scopus
  14. Z. Itoh, R. Honda, and K. Hiwatashi, “Motilin induced mechanical activity in the canine alimentary tract,” Scandinavian Journal of Gastroenterology. Supplement, vol. 11, no. 39, pp. 93–110, 1976. View at Google Scholar · View at Scopus
  15. G. Vantrappen, J. Janssens, T. L. Peeters, S. R. Bloom, N. D. Christofides, and J. Hellemans, “Motilin and the interdigestive migrating motor complex in man,” Digestive Diseases and Sciences, vol. 24, no. 7, pp. 497–500, 1979. View at Publisher · View at Google Scholar · View at Scopus
  16. T. L. Peeters, V. Bormans, and G. Vantrappen, “Comparison of motilin binding to crude homogenates of human and canine gastrointestinal smooth muscle tissue,” Regulatory Peptides, vol. 23, no. 2, pp. 171–182, 1988. View at Publisher · View at Google Scholar · View at Scopus
  17. G. van Assche, I. Depoortere, T. Thijs et al., “Contractile effects and intracellular Ca2+ signalling induced by motilin and erythromycin in the circular smooth muscle of human colon,” Neurogastroenterology and Motility, vol. 13, no. 1, pp. 27–35, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Tsukamoto, N. Kuboyama, M. Yamano, T. Nakazawa, and T. Suzuki, “In vitro pharmacological profile of SK-896, a new human motilin analogue,” Pharmacology, vol. 60, no. 3, pp. 128–135, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Mizumoto, I. Sano, Y. Matsunaga, O. Yamamoto, Z. Itoh, and K. Ohshima, “Mechanism of motilin-induced contractions in isolated perfused canine stomach,” Gastroenterology, vol. 105, no. 2, pp. 425–432, 1993. View at Google Scholar · View at Scopus
  20. H. Nakajima, E. Mochiki, A. Zietlow, K. Ludwig, and T. Takahashi, “Mechanism of interdigestive migrating motor complex in conscious dogs,” Journal of Gastroenterology, vol. 45, no. 5, pp. 506–514, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Takahashi, “Mechanism of interdigestive migrating motor complex,” Journal of Neurogastroenterology and Motility, vol. 18, no. 3, pp. 246–257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. S. A. Chung, O. Rotstein, G. R. Greenberg, and N. E. Diamant, “Mechanisms coordinating gastric and small intestinal MMC: role of extrinsic innervation rather than motilin,” The American Journal of Physiology, vol. 267, no. 5, pp. G800–G809, 1994. View at Google Scholar · View at Scopus
  23. V. Annese, G. Lombardi, V. Frusciante, U. Germani, A. Andriulli, and G. Bassotti, “Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus,” Alimentary Pharmacology and Therapeutics, vol. 11, no. 3, pp. 599–603, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. B. J. Kendall, A. Chakravarti, E. Kendall, I. Soykan, and R. W. McCallum, “The effect of intravenous erythromycin on solid meal gastric emptying in patients with chronic symptomatic post-vagotomy-antrectomy gastroparesis,” Alimentary Pharmacology and Therapeutics, vol. 11, no. 2, pp. 381–385, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. S. S. Sharma, N. Bhargava, and S. C. Mathur, “Effect of oral erythromycin on colonic transit in patients with idiopathic constipation. A pilot study,” Digestive Diseases and Sciences, vol. 40, no. 11, pp. 2446–2449, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Minami, H. Nishibayashi, Y. Shinomura, and Y. Matsuzawa, “Effects of erythromycin in chronic idiopathic intestinal pseudo-obstruction,” Journal of Gastroenterology, vol. 31, no. 6, pp. 855–859, 1996. View at Publisher · View at Google Scholar · View at Scopus
  27. J. S. Jameson, J. Rogers, J. J. Misiewicz, A. H. Raimundo, and M. M. Henry, “Oral or intravenous erythromycin has no effect on human distal colonic motility,” Alimentary Pharmacology and Therapeutics, vol. 6, no. 5, pp. 589–595, 1992. View at Google Scholar · View at Scopus
  28. J. M. Polak, A. G. E. Pearse, and C. M. Heath, “Complete identification of endocrine cells in the gastrointestinal tract using semithin thin sections to identify motilin cells in human and animal intestine,” Gut, vol. 16, no. 3, pp. 225–229, 1975. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Kishimoto, J. M. Polak, A. M. J. Buchan et al., “Motilin cells investigated by the use of region-specific antisera,” Virchows Archiv B Cell Pathology Including Molecular Pathology, vol. 36, no. 1, pp. 207–218, 1981. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Sakai, M. Satoh, H. Koyama et al., “Localization of motilin-immunopositive cells in the rat intestine by light microscopic immunocytochemistry,” Peptides, vol. 15, no. 6, pp. 987–991, 1994. View at Publisher · View at Google Scholar · View at Scopus
  31. P. U. Heitz, M. Kasper, G. Krey, J. M. Polak, and A. G. Pearse, “Immunoelectron cytochemical localization of motilin in human duodenal enterochromaffin cells,” Gastroenterology, vol. 74, no. 4, pp. 713–717, 1978. View at Google Scholar · View at Scopus
  32. A. G. E. Pearse, J. M. Polak, S. R. Bloom, C. Adams, J. R. Dryburgh, and J. C. Brown, “Enterochromaffin cells of the mammalian small intestine as the source of motilin,” Virchows Archiv B Cell Pathology, vol. 16, no. 1, pp. 111–120, 1974. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Kitamura, J. Yamada, N. Y. Calingasan, and T. Yamashita, “Histologic and immunocytochemical study of endocrine cells in the gastrointestinal tract of the cow and calf,” The American Journal of Veterinary Research, vol. 46, no. 6, pp. 1381–1386, 1985. View at Google Scholar · View at Scopus
  34. N. Y. Calingasan, N. Kitamura, J. Yamada, Y. Oomori, and T. Yamashita, “Immunocytochemical study of the gastroenteropancreatic endocrine cells of the sheep,” Acta Anatomica, vol. 118, no. 3, pp. 171–180, 1984. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Leming, J. Broad, S. J. Cozens et al., “GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs,” Neurogastroenterology and Motility, vol. 23, no. 10, pp. e958–e410, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. H. P. Parkman, A. P. Pagano, M. A. Vozzelli, and J. P. Ryan, “Gastrokinetic effects of erythromycin: myogenic and neurogenic mechanisms of action in rabbit stomach,” The American Journal of Physiology, vol. 269, no. 3, pp. G418–G426, 1995. View at Google Scholar · View at Scopus
  37. G. J. Sanger, Y. Wang, A. Hobson, and J. Broad, “Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists,” British Journal of Pharmacology, vol. 170, no. 7, pp. 1323–1332, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Boivin, L. R. Pinelo, S. St.-Pierre, and P. Poitras, “Neural mediation of the motilin motor effect on the human antrum,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 272, no. 1, pp. G71–G76, 1997. View at Google Scholar · View at Scopus
  39. E. Deloose, P. Janssen, I. Depoortere, and J. Tack, “The migrating motor complex: control mechanisms and its role in health and disease,” Nature Reviews Gastroenterology and Hepatology, vol. 9, no. 5, pp. 271–285, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. Z. Itoh, S. Takeuchi, I. Aizawa et al., “Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs,” The American Journal of Digestive Diseases, vol. 23, no. 10, pp. 929–935, 1978. View at Publisher · View at Google Scholar · View at Scopus
  41. Z. Itoh, I. Aizawa, R. Honda, S. Takeuchi, and K. Mori, “Regular and irregular cycles of interdigestive contractions in the stomach,” The American Journal of Physiology, vol. 238, no. 2, pp. G85–G90, 1980. View at Google Scholar · View at Scopus
  42. Z. Itoh, R. Honda, and I. Aizawa, “Diurnal pH changes in duodenum of conscious dogs,” The American Journal of Physiology, vol. 238, no. 2, pp. G91–G96, 1980. View at Google Scholar · View at Scopus
  43. Z. Itoh and I. Takahashi, “Periodic contractions of the canine gallbladder during the interdigestive state,” The American Journal of Physiology, vol. 240, no. 2, pp. G183–G189, 1981. View at Google Scholar · View at Scopus
  44. W.-D. Xu, X. Jiang, L. Lan, H.-X. Tong, C.-H. Wang, and B.-X. Wang, “Motilin receptor expression in the interstitial cells of Cajal,” Chinese Journal of Pediatrics, vol. 49, no. 4, pp. 255–260, 2011. View at Google Scholar · View at Scopus