HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients

Table 1

Baseline metabolic parameters of 75 patients with genotype 1 chronic hepatitis C on the basis of gender.

	All patients	Male	Female	OR 95% CI
Number of patients	75	45	30
Age (median; range)	49 (26–67)	48 (26–67)	49 (31–67)	1.01 (0.97–1.05)	0.58
BMI (median; range)	23.6 (19.4–29.6)	24.1 (21.3–29.6)	22.5 (19.4–28.7)	0.82 (0.68–0.99)	0.047
Fasting glucose (median; range)	5.03 (2.20–6.88)	5.10 (2.41–6.78)	4.83 (2.21–6.52)	0.82 (0.54–1.26)	0.37
Fasting insulin (median; range)	8.84 (1.4–27.9)	8.51 (1.40–21.3)	9.1 (2.0–33.1)	1.02 (0.97–1.08)	0.40
HOMA-IR (median; range)	1.9 (0.3–10.5)	1.9 (0.3–10.3)	2.05 (0.3–10.5)	1.09 (0.89–1.34)	0.42
Leptin (median; range)	9.2 (2.2–55)	6.3 (2.2–29.2)	15.4 (3–55)	1.14 (1.06–1.23)	<0.000
Adiponectin (median; range)	13.5 (4.5–36.1)	12.2 (4.5–23.3)	17.05 (7.1–36.1)	1.16 (1.05–1.23)	0.002