Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis

Table 1

Characteristics of the nine studies included in this paper.

Trials	Year	Type of study	Number of pts	Number of  pts		Dose of medicine				Dose of RT	Time interval	Results
				Cape	5-Fu	Cape	DI (mg/m^2/w)	5-Fu	DI (mg/m^2/w)			pCR	SSS	SD	OS	DFS	LR
Hofheinz et al. [12]	2012	RCT	392	197	195	2500 mg/m^2/day days repeated day22; (2 cycles before and after RT); 1650 mg/m^2/day; (during RT)	10113	500 mg/m^2/day days repeated day22 (2 cycles before and after RT) 225 mg/m^2/day (during RT)	966	50.4 Gy/25 Fr	4–6 weeks
O’Connell et al. [13]	2014	RCT	1,608	802	806	1650 mg/m^2/day 5 days/weeks	8250	225 mg/m^2/day; 5 days/weeks	1125	T3N0: 50.4 Gy/25 Fr; T4/N+: 55.8 Gy/25 Fr	6–8 weeks
Chen et al. [15]	2012	Retro	74	47	27	1700 mg/m^2/day 5 days/weeks	8500	350 mg/m^2/day; 5 days/weeks	700	45–50.4 Gy/25 Fr,	6 weeks
Chan et al. [14]	2010	Retro	102	34	68	1650 mg/m^2/day 5 days/weeks	8250	20 mg/kg/day days	N/A	50 Gy/25 Fr	8 weeks
Yerushalmi et al. [20]	2006	Retro	89	43	46	1650 mg/m^2/day 5 days/weeks	8250	180 mg/m^2/day; 5 days/weeks	900	50 Gy/25 Fr	7–7.5 weeks (median)
Das et al. [16]	2006	Retro	178	89	89	1650 mg/m^2/day 5 days/weeks 58 pts; 1650 mg/m^2/day 7 days/weeks 31 pts	9399	300 mg/m^2/day; 5 days/weeks	1500	52.5 Gy/25 Fr	N/A
Kim et al. [17]	2007	Retro	278	133	145	1650 mg/m^2/day 7 days/weeks	11550	400 mg/m^2/day; 3 days/weeks	480	50 Gy/25 Fr	6 weeks
Ramani et al. [19]	2010	Retro	196	99	97	1650 mg/m^2/day 5 days/weeks	8250	1000 mg/m^2/day; days	1600	50.4–54 Gy/25 Fr	6–8 weeks
Kim et al. [18]	2006	Retro	224	97	127	1650 mg/m^2/day days repeated day22	9240	500 mg/m^2/day; 5 days/weeks	1000	50.4 Gy/25 Fr	6 weeks

RCT, randomized clinical trial; retro, retrospective study; number of pts, number of patients; cape, capecitabine; RT, radiotherapy; LR, local recurrence; pCR, pathological complete response; SSS, sphincter saving surgery; OS, overall survival; DFS, disease-free survival; SD, surgical downstaging; DI, dose intensity; RR, risk ratio; CI, confidence interval.
: time interval between radiotherapy and surgery.