Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma

<div>Immunofluorescent staining shows strong induction of<i> Ccn2/Ctgf</i> promoter activity in DDC-induced mouse HPC. (a) Dual staining for EpCAM and GFP proteins was carried out on liver sections from mice that carried<i> Ccn2/Ctgf</i> promoter driven GFP<i> (Ctgfp-GFP)</i> transgene under normal conditions or after 20-day DDC feeding. (b) Double staining for HNF4<i>α</i> and GFP showed little<i> Ccn2/Ctgf</i> promoter activity in mature hepatocytes of damaged livers from mice that were fed DDC for 20 days. Scale bar: 35 <i>μ</i>m.</div>

Gastroenterology Research and Practice

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Figure 2

Figure 2: Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma 