Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma

Figure 4

Localization of CCN2/CTGF protein in CK19⁺ human HPC that are surrounded by intratumoral α-SMA⁺ myofibroblast cells. Immunofluorescent staining for CCN2/CTGF in combination with α-SMA (a) or CK19 (b) was carried out on human CCA sections. (d) The immunofluorescent staining revealed CCN2/CTGF localization in CK19⁺ human HCC tumor cells. (c and e) IH-CCA and HCC tumors in (b) and (d) were histologically analyzed by H&E staining. Scale bar: 30 μm.

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