Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases

Table 2

Immunohistochemical expression of MMP-2, MMP-7, and MMP-9 in glandular tubes and inflammatory cells in tissues of ulcerative colitis and Crohn’s disease.

Protein expression	Ulcerative colitis (UC)								Crohn’s disease (CD)
	Glandular cells (% of cases)				Inflammatory cells (% of cases)				Glandular cells (% of cases)				Inflammatory cells (% of cases)
	0	1	2	3	0	1	2	3	0	1	2	3	0	1	2	3
MMP-2	3.3	73.3	16.7	6.7^1	18.2	72.2	9.1	0	20	10	10	60^2	9.1	81.8	9.1	0
MMP-7	54.9	29	16.1	0	6.4	35.5	32.3	25.8	0	60	30	10	0	20	20	60
MMP-9	6.7	33.3	23.3	36.7^3	3.2	32.3	25.8	38.7^5	16.7	50	25	8.3^4	33.3	41.7	16.7	8.3^6

1  versus 2 = 0.009; 3 versus 4 = 0.042; 5 versus 6 = 0.003.
0: absent, 1: weak, 2: moderate, and 3: strong.