Gastroenterology Research and Practice / 2016 / Article / Tab 2

Research Article

Serum Immunoglobulin A (IgA) Level Is a Potential Biomarker Indicating Cirrhosis during Chronic Hepatitis B Infection

Table 2

Demographic and clinical characteristics of HBV-infected patients with compensated and decompensated cirrhosis at baseline.

Compensated ()Decompensated ()

Gender (male/female) 57/1527/50.745
Age (y) 52.3 ± 10.855.7 ± 11.70.303
Total protein (g/L)62.2 ± 7.358.6 ± 8.10.027
Albumin (g/L) 32.0 ± 4.025.0 ± 4.8<0.001
ALT (U/L) 21.0 (15.0–32.8)33.5 (14.0–58.8)0.145
AST (U/L) 31.0 (24.3–51.3)46.5 (28.3–100.3)0.001
Total bilirubin (μmol/L) 26.0 (16.0–43.0)59.5 (25.0–179.0)0.001
INR1.34 ± 0.271.52 ± 0.310.005
Creatinine (mmol/L)74.0 (63.0–86.0)106.0 (70.3–124.0)0.001
Platelets (×109/L)62.0 (39.5–90.5)72.0 (36.0–89.0)0.001
Hemoglobin (g/L)100.5 (81.0–124.0)100.0 (88.5–116.0)0.998
Encephalopathy ()05
Hepatorenal syndrome ()04
Ascites ()1032
Gastrointestinal bleeding ()015
IgM (mg/dL)151.0 (113.0–201.8)159.5 (116.5–196.0)0.833
IgA (mg/dL)370.5 (244.3–506.5)525.0 (378.3–673.5)0.002
IgG (mg/dL)1644.5 (1225.0–2124.8)1969.0 (1302.5–2274.3)0.204

Data are expressed as , mean ± SD, or median (interquartile range).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; INR, international normalized ratio; Ig, immunoglobulin.

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