Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis
Table 1
Demographic and baseline characteristics of patients with nonmetastatic signet-ring cell carcinoma of the colon from the SEER database and stratification by age at diagnosis.
Characteristics
All patients
≤35 years
>35 years
value (Pearson )
N (%)
776 (100.0)
78 (10.0)
698 (90.0)
Median follow-up, months
27
23
28
Male gender, n (%)
432 (55.7)
42 (53.8)
390 (55.9)
0.732 (0.12)
Years of diagnosis, n (%)
0.029 (4.76)
1988–2003
309 (39.8)
40 (51.3)
269 (38.5)
2004–2011
467 (60.2)
38 (48.7)
429 (61.5)
Primary site, n (%)
0.001 (10.31)
Right colon
612 (78.9)
50 (64.1)
562 (80.5)
Left colon
164 (21.1)
28 (35.9)
136 (19.5)
Race, n (%)
<0.001 (19.84)
White
637 (82.1)
50 (64.1)
587 (84.1)
Black
83 (10.7)
16 (20.5)
67 (9.6)
56 (7.1)
12 (15.4)
44 (6.3)
Pathology grade, n (%)
0.987 (0.001)
Well/moderate
80 (10.3)
8 (10.3)
72 (10.3)
Poor/undifferentiated
696 (89.7)
70 (89.7)
626 (89.7)
Tumor size, n (%)
0.123 (2.49)
≤4.0 cm
249 (32.1)
19 (24.4)
230 (33.0)
>4.0 cm
527 (67.9)
59 (75.6)
468 (67.0)
LNH, n (%)
0.023 (5.19)
≤18
343 (44.2)
25 (32.1)
318 (45.6)
>18
433 (55.8)
53 (67.9)
380 (54.4)
T stage, n (%)
0.164 (5.11)
T1
24 (3.1)
2 (2.5)
22 (3.1)
T2
31 (4.0)
1 (1.3)
30 (4.3)
T3
453 (58.4)
40 (51.3)
413 (59.2)
T4
268 (34.5)
35 (44.9)
233 (33.4)
N stage, n (%)
<0.001 (17.08)
N0
195 (25.1)
8 (10.2)
187 (26.8)
N1
181 (23.3)
13 (16.7)
168 (24.1)
N2
400 (51.6)
57 (73.1)
343 (49.1)
TNM stage, n (%)
0.006 (10.27)
I
35 (4.5)
1 (1.3)
34 (4.9)
II
160 (20.6)
7 (9.0)
153 (21.9)
III
581 (74.9)
70 (89.7)
511 (73.2)
LNH: number of lymph nodes harvested. Native Americans, Asians, Pacific Islanders, and unknown.
