Identification of the Key Genes and Pathways in Esophageal Carcinoma

Table 3

GO annotation of upregulated DEGs in EC.

GO ID	GO term	Count	-value	FDR
Biological process
GO:0007049	Cell cycle	152	4.10E − 13	7.59E − 10
GO:0022402	Cell cycle process	118	3.44E − 12	6.36E − 09
GO:0022403	Cell cycle phase	90	2.00E − 10	3.71E − 07
GO:0000278	Mitotic cell cycle	82	5.34E − 10	9.87E − 07
GO:0051301	Cell division	67	8.80E − 09	1.63E − 05
GO:0000279	M phase	70	6.27E − 08	1.16E − 04
GO:0000087	M phase of mitotic cell cycle	49	3.38E − 06	0.0062547
GO:0000280	Nuclear division	48	4.65E − 06	0.0086014
GO:0007067	Mitosis	48	4.65E − 06	0.0086014
GO:0048285	Organelle fission	49	6.41E − 06	0.011854
GO:0033554	Cellular response to stress	95	2.02E − 05	0.0373322
Cellular component
GO:0031974	Membrane-enclosed lumen	276	1.12E − 10	1.65E − 07
GO:0043233	Organelle lumen	270	2.41E − 10	3.56E − 07
GO:0043232	Intracellular non-membrane-bounded organelle	359	8.74E − 10	1.29E − 06
GO:0043228	Non-membrane-bounded organelle	359	8.74E − 10	1.29E − 06
GO:0070013	Intracellular organelle lumen	259	4.54E − 09	6.71E − 06
GO:0031981	Nuclear lumen	216	1.90E − 08	2.80E − 05
GO:0000775	Chromosome, centromeric region	36	2.52E − 08	3.72E − 05
GO:0005829	Cytosol	192	1.36E − 06	0.0020016
GO:0015630	Microtubule cytoskeleton	92	4.62E − 06	0.0068255
GO:0000793	Condensed chromosome	32	6.75E − 06	0.009972
GO:0000779	Condensed chromosome, centromeric region	21	7.55E − 06	0.011151
GO:0044427	Chromosomal part	69	9.92E − 06	0.0146408
GO:0005635	Nuclear envelope	43	1.37E − 05	0.0202598
GO:0000777	Condensed chromosome kinetochore	19	1.48E − 05	0.0219025
GO:0005694	Chromosome	78	1.75E − 05	0.02589
GO:0000776	Kinetochore	22	2.72E − 05	0.0401619
Molecular function
GO:0000166	Nucleotide binding	305	5.53E − 06	0.0090275
GO:0017076	Purine nucleotide binding	266	5.55E − 06	0.0090714
GO:0030554	Adenyl nucleotide binding	223	1.07E − 05	0.0175078
GO:0001883	Purine nucleoside binding	225	1.49E − 05	0.0242774
GO:0032555	Purine ribonucleotide binding	252	2.35E − 05	0.0383944
GO:0032553	Ribonucleotide binding	252	2.35E − 05	0.0383944
GO:0001882	Nucleoside binding	225	2.44E − 05	0.0398342

EC: esophageal carcinoma; FDR: false discovery rate.