Research Article

Identification of the Key Genes and Pathways in Esophageal Carcinoma

Table 5

The KEGG pathway enrichment of up-regulated DEGs in EC.

KEGG IDKEGG termsCountFDRGenes

hsa04110Cell cycle197.86E − 08CDK6, CCNE2, CCNB2, FZR1, CCNA2, CDC7, YWHAQ, MCM7, CCNE1, CDK4, E2F5, CCNB1, MAD2L1, CDC25B, MCM6, BUB1, RBL1, MCM2, CDK1
hsa03013RNA transport201.09E − 07RAN, EIF3H, NUP43, UBE2I, NUP133, MAGOHB, POP5, THOC5, CLNS1A, NUP205, GEMIN6, NUP93, NUP62, SUMO1, EIF2S2, NUP153, RANGAP1, NUP160, RPP25, DDX20
hsa04115p53 signaling pathway52.90E − 06CCNE2, CCNB2, CCNE1, CCNB1, CDK1
hsa04914Progesterone-mediated oocyte maturation81.42E − 05CCNB2, FZR1, CCNA2, CCNB1, MAD2L1, CDC25B, BUB1, CDK1
hsa03050Proteasome91.56E − 05PSMD7, SHFM1, PSMD3, PSMA5, PSMB1, PSMB3, PSMA3, PSMD4, PSMA7
hsa03040Spliceosome151.66E − 05SNRPC, SRSF9, XAB2, MAGOHB, NAA38, BUD31, SNRPF, NHP2L1, SRSF3, PQBP1, USP39, SNRNP40, SNRPD1, SNRPD2, SF3B2
hsa03030DNA replication84.24E − 05RNASEH2A, RNASEH1, MCM7, POLE2, MCM6, RNASEH2C, MCM2, RFC4
hsa03008Ribosome biogenesis in eukaryotes114.37E − 05UTP18, RAN, UTP15, NOP56, DKC1, POP5, FBL, NHP2L1, TCOF1, GNL3L, RPP25
hsa03440Homologous recombination74.37E − 05SHFM1, MRE11A, RAD54B, XRCC2, RAD54L, BLM, TOP3A
hsa04114Oocyte meiosis88.96E − 05CCNE2, CCNB2, YWHAQ, CCNE1, CCNB1, MAD2L1, BUB1, CDK1
hsa05162Measles40.0001531CDK6, CCNE2, CCNE1, CDK4
hsa05222Small cell lung cancer40.0001531CDK6, CCNE2, CCNE1, CDK4
hsa05200Pathways in cancer230.0001815VEGFB, CDK6, MTOR, FH, CCNE2, LEF1, BIRC5, CCNE1, CDK4, TCEB1, MSH6, EGF, FZD2, TFG, CKS1B, TRAF4, HSP90AA1, TRAF3, PPARG, HSP90AB1, FGF12, PIAS4, STK4
hsa00510N-Glycan biosynthesis80.000312RFT1, ALG10, RPN2, ALG10B, ALG1, MOGS, ALG5, B4GALT2

EC: esophageal carcinoma; FDR: false discovery rate.