Identification of the Key Genes and Pathways in Esophageal Carcinoma

Table 6

The KEGG pathway enrichment of downregulated DEGs in EC.

KEGG ID	KEGG terms	Count	FDR	Genes
hsa04144	Endocytosis	23	5.22E − 06	STAMBP, RAB11FIP5, SH3KBP1, KIT, FOLR2, F2R, TGFBR2, VPS4B, SH3GLB1, CHMP5, CXCR2, PDGFRA, CLTB, FOLR1, STAM2, ARAP2, DAB2, EEA1, PDCD6IP, RAB11FIP2, CBL, EPN3, VPS37B
hsa04510	Focal adhesion	19	0.000354	ITGA1, ZYX, LAMB2, MYLK, IGF1, CCND2, ITGA2, RAP1A, PDGFRA, ITGA5, TNXB, VWF, PIK3R1, JUN, COL6A2, BCL2, ROCK1, MYL12A, THBS3
hsa04270	Vascular smooth muscle contraction	14	0.000383	JMJD7-PLA2G4B, MYLK, ADCY9, GNA13, PRKG1, ITPR2, PPP1R12B, GNAQ, MYH11, ACTG2, ROCK1, PLA2G2A, MRVI1, ITPR1
hsa00330	Arginine and proline metabolism	4	0.000425	ALDH7A1, MAOB, GATM, MAOA
hsa04360	Axon guidance	15	0.000456	EPHA1, ROBO1, SEMA4B, DPYSL2, ABLIM3, PPP3CC, NCK2, GNAI2, SEMA3F, PPP3CA, RGS3, NTN1, ROCK1, PPP3CB, EFNB2
hsa04020	Calcium signaling pathway	5	0.00046	PPP3CC, ITPR2, PPP3CA, PPP3CB, ITPR1
hsa04662	B cell receptor signaling pathway	4	0.000508	PPP3CC, JUN, PPP3CA, PPP3CB
hsa05014	Amyotrophic lateral sclerosis	3	0.000583	PPP3CC, PPP3CA, PPP3CB
hsa00340	Histidine metabolism	3	0.000583	ALDH7A1, MAOB, MAOA
hsa04720	Long-term potentiation	6	0.000623	PPP3CC, ITPR2, GNAQ, PPP3CA, PPP3CB, ITPR1
hsa04114	Oocyte meiosis	6	0.00068	ADCY9, PPP3CC, ITPR2, PPP3CA, PPP3CB, ITPR1
hsa04730	Long-term depression	10	0.000701	JMJD7-PLA2G4B, IGF1, GNA13, PRKG1, ITPR2, PPP2CB, GNAQ, GNAI2, PLA2G2A, ITPR1
hsa04141	Protein processing in endoplasmic reticulum	16	0.000709	SEC63, UBE2J1, EIF2AK3, ATF6, CRYAB, UBE2D3, DNAJB2, SEC31B, MAN1A1, ERO1L, BCL2, HERPUD1, DNAJC3, UBQLN2, RAD23B, LMAN1
hsa04912	GnRH signaling pathway	12	0.000736	JMJD7-PLA2G4B, MMP2, ADCY9, MAP3K3, HBEGF, ITPR2, MAPK7, GNAQ, MAP3K4, JUN, PLA2G2A, ITPR1
hsa00280	Valine, leucine, and isoleucine degradation	8	0.000738	ALDH7A1, ACADM, HMGCS1, MUT, ABAT, ACADSB, ACAD8, AUH

EC: esophageal cancer; FDR: false discovery rate.