Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats

Table 1

Influence of Escherichia coli Nissle 1917 (Mutaflor) and rifaximin on morphological signs of colonic damage in rats without or with acetic acid-induced colitis observed 8 days after rectal administration of saline or acetic acid solution (colitis).

	Morphological changes
	Grading of colonic damage (0–2)	Inflammatory infiltration (0–3)	Depth of damage (0–3)	Fibrosis (0–3)
Saline (control)	0	0	0	0
Mutaflor	0	0	0	0
Rifaximin	0	0	0	0
Rifaximin + Mutaflor	0	0	0	0
Colitis + NaCl	3	2-3	2	1-2
Colitis + Mutaflor	3	2-3	1-2	1
Colitis + rifaximin	2-3	1-2	1-2	1
Colitis + rifaximin + Mutaflor	2	1	1	0-1

Numbers represent the predominant histological grading in each group.