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Gastroenterology Research and Practice
Volume 2016, Article ID 3432640, 9 pages
Review Article

Risk and Surveillance of Cancers in Primary Biliary Tract Disease

1Department of Internal Medicine, University of North Dakota, Fargo, ND 58102, USA
2Department of General Internal Medicine, MD Anderson Cancer Center, Houston, TX 77030, USA

Received 21 January 2016; Revised 14 April 2016; Accepted 18 May 2016

Academic Editor: Kerstin Schütte

Copyright © 2016 Valery Hrad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Primary biliary diseases have been associated in several studies with various malignancies. Understanding the risk and optimizing surveillance strategy of these malignancies in this specific subset of patients are an important facet of clinical care. For instance, primary sclerosing cholangitis is associated with an increased risk for cholangiocarcinoma (which is very challenging to diagnose) and when IBD is present for colorectal cancer. On the other hand, primary biliary cirrhosis patients with cirrhosis or not responding to 12 months of ursodeoxycholic acid therapy are at increased risk of hepatocellular carcinoma. In this review we will discuss in detail the risks and optimal surveillance strategies for patients with primary biliary diseases.