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Gastroenterology Research and Practice
Volume 2016 (2016), Article ID 3521453, 10 pages
http://dx.doi.org/10.1155/2016/3521453
Research Article

Annexin A2 Coordinates STAT3 to Regulate the Invasion and Migration of Colorectal Cancer Cells In Vitro

1Department of Radiology, China-Japan Union Hospital, Jilin University, Changchun 130033, China
2Department of Ultrasonography, China-Japan Union Hospital, Jilin University, Changchun 130033, China
3China-Japan Union Hospital, Jilin University, Changchun 130033, China

Received 16 October 2015; Revised 11 February 2016; Accepted 24 March 2016

Academic Editor: Massimo Pancione

Copyright © 2016 Dianhui Xiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study aimed to reveal the expression of STAT3 and Anxa 2 in CRC specimens and to investigate the effects of STAT3 and Anxa 2 signaling on the proliferation, invasion, and migration in CRC Caco-2 cells. Results demonstrated that both Anxa 2 and STAT3 were highly expressed in CRC specimens in both mRNA and protein levels, with or without phosphorylation (Tyrosine 23 in Anxa 2 and Tyrosine 705 in STAT3). And the upregulated Anxa 2 promoted the phosphorylation of STAT3 (Tyrosine 705) in CRC Caco-2 cells. The upregulated Anxa 2 promoted the proliferation, migration, and invasion of Caco-2 cells in vitro. Moreover, the STAT3 knockdown also repressed the proliferation, migration, and invasion of Caco-2 cells. In conclusion, the overexpressed Annexin A2 regulated the proliferation, invasion, and migration in CRC cells in an association with STAT3.