Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis

Table 2

Study quality and sensitivity/specificity for diagnosis.

Study	Quality	Mucinous versus nonmucinous			Malignant versus benign
		KRAS mutations	LOH	DNA quantity	KRAS mutations	LOH	DNA quantity
Khalid et al., 2005 [18]	Low	NR	NR	NR	91/86	NR	NR
Schoedel et al., 2006 [19]	Low	NR	NR	NR	50/83	75/64	NR
Sreenarasimhaiah et al., 2009 [20]	Low	33/93	50/71	NR	NR	NR	NR
Shen et al., 2009 [21]	Medium	57/100	43/93	33/100	83/76	83/83	83/93
Sawhney et al., 2009 [22]	High	11/100	70/100	29/100	20/93	100/50	40/79
Khalid et al., 2009 [23]	High	45/96	67/68	45/68	53/73	90/67	75/86
Talar-Wojnarowska et al., 2012 [24]	High	65/97	NR	NR	NR	NR	NR
Chai et al., 2013 [25]	Medium	56/100	NR	NR	NR	NR	NR

Data are reported as the sensitivity/specificity of the different molecular tests for diagnosis of mucinous versus nonmucinous or malignant versus benign lesions. NR: not reported.