Research Article
Molecular Analyses of Aspirated Cystic Fluid for the Differential Diagnosis of Cystic Lesions of the Pancreas: A Systematic Review and Meta-Analysis
Table 4
Accuracy measures of molecular diagnostic analyses for the differentiation of malignant from benign pancreatic cysts.
| Test | Accuracy measure | Pooled summary measure# (95% CI) | value of heterogeneity test |
| KRAS mutation tests | Sensitivity | 0.59 (0.46–0.71) | 0.02‡ | Specificity | 0.78 (0.71–0.85) | 0.25 | Positive likelihood ratio | 3.03 (1.79–5.11) | 0.20 | Negative likelihood ratio | 0.57 (0.32–0.99) | 0.03‡ | Diagnostic odds ratio | 7.45 (2.15–25.81) | 0.11 |
| LOH tests | Sensitivity | 0.89 (0.78–0.96) | 0.57 | Specificity | 0.69 (0.60–0.76) | 0.15 | Positive likelihood ratio | 2.57 (1.85–3.57) | 0.28 | Negative likelihood ratio | 0.19 (0.09–0.39) | 0.81 | Diagnostic odds ratio | 15.62 (6.28–38.87) | 0.81 |
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#Random effects model. Chi-square or Fisher’s exact test for heterogeneity. ‡.
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