First author [ref.] Year Cancer Country Sample size Methods for UCA1 detecting Cut-off value for UCA1 UCA1 expression Study endpoints (HR, 95% CI) Data source Follow-up time (months) High expression High with LNM High with DM Low expression Low with LNM Low with DM Han [17 ] 2014 CRC China 80 qRT-PCR Mean value 37 17 7 43 18 7 OS OS (U), 3.02 (1.19–7.68) Curve Mean 42.6 Li [22 ] 2014 ESCC China 90 qRT-PCR Mean value 41 22 NA 49 12 NA. OS OS (U), 2.93 (1.72–6.21) Direct Median 43 OS (M), 2.63 (1.42–5.87) Direct Wang [13 ] 2015 HCC China 98 qRT-PCR Median value 49 NA 30 49 NA 11 OS OS (U), 2.69 (1.56–4.64) Direct Up to 60 OS (M), 1.86 (1.08–3.21) Direct Zheng [15 ] 2015 GC China 112 qRT-PCR Median value 56 35 NA 56 37 NA OS, DFS OS (U), 2.35 (1.40–4.51) Direct Up to 60 OS (M), 2.35 (1.22–4.52) Direct DFS (U), 2.90 (1.51–5.80) Direct DFS (M), 2.55 (1.33–4.97) Direct Yang [14 ] 2015 HCC Korea 240 Illumina expression beadchip Median value 120 NA NA 120 NA NA OS, DFS OS (U), 1.99 (0.84–4.69) Direct Up to 120 DFS (U), 2.35 (1.07–5.17) Direct DFS (M), 2.40 (1.09–5.27) Direct Ni [18 ] 2015 CRC China 54 qRT-PCR Median value 27 12 6 27 5 1 OS OS (U), 5.07 (1.25–20.54) Available data Up to 50 OS (M), 3.14 (1.17–8.41) Available data Chen [21 ] 2015 PDAC USA 63 Affymetrix 2.0 microarray NA NA NA NA NA NA NA OS OS (U), 2.76 (1.15–6.61) Available data Median 21 Tao [19 ] 2015 CRC China 80 qRT-PCR Fourth quartile 20 13 NA 60 21 NA OS OS (U), 2.46 (1.26–4.78) Direct Up to 72 OS (M), 2.00 (1.01–2.98) Direct Bian [20 ] 2016 CRC China 90 qRT-PCR Median value 45 30 8 45 23 4 OS OS (U), 3.27 (1.44–7.41) Direct Up to 80 OS (M), 2.40 (1.04–5.50) Direct 105 NA NA NA NA NA NA OS OS (U), 1.71 (1.21–2.40) Curve Up to 120 Shang [16 ] 2016 GC China 77 qRT-PCR NA NA NA NA NA NA NA DFS DFS (M), 2.54 (1,09–5.92) Direct Up to 72
NA, not available; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; LNM, lymph node metastasis; DM, distant metastasis; OS, overall survival; DFS, disease-free survival; U, univariate analysis; M, multivariate analysis; Curve, Kaplan–Meier curve; 