Outcomes of Radiofrequency Ablation for Dysplastic Barrett’s Esophagus: A Comprehensive Review

Table 1

Efficacy of radiofrequency ablation for Barrett’s esophagus with low-grade dysplasia and intestinal metaplasia.

Author/year	Study design	Setting	Number	BE length	ER before RFA	Efficacy (end of treatment)		Recurrence		Complications
						CE-D (%)	CE-IM (%)	D (%)	IM (%)
Sharma et al. 2008 [9]	RS	SC	10	4.4 (mean)	0%	90%	90%	0%	0%	10% (1 bleeding)
Sharma et al. 2009 [10]	PS	SC	38	4 (median)	0%	95%	87%	NR	NR	2,6% (1 stricture)
Shaheen et al. 2009 [8]	RCT	MC	42	4.6 (mean)	NR	90.5%	81%	—	—	9.5% (5 stricture, 1 bleeding, 2 chest pain)
Pouw et al. 2010 [11]	PS	MC	11	8 (median)	96%	91%	91%	0%	0%	8% (1 bleeding, 1
Lyday et al. 2010 [12]	RS	MC	13	3 (median)	0%	100%	85%	NR	NR	3.9% (9 stricture, 3 bradycardia, 4 bleeding, 1 superficial mucosal injury, 1
Shaheen et al. 2011 [13]	RCT	MC	52	4.5 (mean)	9%	98%	98%	2%	2%	10.9% (1 bleeding, 3 chest pain, 9 esophageal
Okoro et al. 2012 [14]	RS	SC	13	4.5 (mean)	0%	61.5%	61.5%	NR	NR	16.6% (10 stricture, 5 chest
Bulsiewicz et al. 2013 [15]	RS	SC	44	4 (mean)	9%	93%	86%	NR	NR	8.2% (18 stricture, 2
Dulai et al. 2013 [16]	RS	SC	ULSBE: 5	10.8 (median)		100%		0%		21% (7% postablative mucosal tears and 14% stricture)
			LSBE: 7	4.7 (median)		100%		0%
Phoa et al. 2014 [4]	RCT	MC	68	4 (mean)	—	92.6%	88.2%	1.6%	10%	19.1% (8 stricture, 3 mucosal laceration)
Small et al. 2015 [5]	RS	MC	45	5 (median)	4.4%	95.6%	77.8%	16%	NR	—

data.
BE: Barrett’s esophagus; ER: endoscopic mucosal resection; RFA: radiofrequency ablation; RCT: randomized controlled trial; PS: prospective study; RS: retrospective study; SC: single center; MC: multicenter; ULSBE: ultra-long segment Barrett’s esophagus; LSBE: long segment Barrett’s esophagus; NR: not reported; CE-D: complete eradication of dysplasia; CE-IM: complete eradication of intestinal metaplasia; D: dysplasia; IM: intestinal metaplasia. : efficacy at end of follow-up.