The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis

Table 1

Characteristics of included studies in the meta-analysis.

Author	Year	Country	Ethnicity	Mean age; (FD/control)	Gender; (male/female)	Definition of FD	Genotyping method	Functional dyspepsia				Controls				HWE	NOS Score
								Total	CC	CT	TT	Total	CC	CT	TT
Holtmann et al. [24]	2004	America	American	46.4 ± 1.9/44.4 ± 1.3	60/108	Rome II	PCR-RFLP	56	34	18	4	112	46	62	4	0	5
Camilleri et al. [25]	2006	America	Caucasian	55/60	44/45	Rome II	Direct sequencing	50	32	10	8	39	17	21	1	0.07	6
Li et al. [32]	2006	China	Chinese	48.9 ± 9.9/46.2 ± 8.9	112/132	Rome II	PCR-RFLP	102	21	41	40	142	38	55	49	0.01	5
Tahara et al. [33]	2008	Japan	Japanese	60.1 ± 13.1/61.1 ± 13.1	130/53	Rome II	PCR-RFLP	89	20	38	31	94	23	48	23	0.84	7
van Lelyveld et al. [34]	2008	Netherlands	Caucasian	42.3 ± 1/41.9 ± 1	115/333	Rome II	Molecular beacon assay	112	48	54	10	336	180	126	30	0.25	6
de Vries et al. [35]	2009	America	American	49.7 ± 12.3/40.1 ± 12.3	182/319	Rome II	Molecular beacon assay	128	60	56	12	373	199	138	36	0.1	5
Oshima et al. [26]	2010	Japan	Japanese	43/45	350/479	Rome III	TaqMan Assay	68	17	29	22	761	191	368	202	0.37	6
Shimpuku et al. [36]	2011	Japan	Japanese	59.2 ± 14.2/37.2 ± 9.13	93/45	Rome III	Direct sequencing	74	14	44	16	64	17	28	19	0.32	8
Kim et al. [27]	2012	Korea	Korean	49 ± 15/47 ± 15	229/372	Rome III	TaqMan Assay	167	52	76	39	434	112	215	107	0.85	8
Park and Uhm [37]	2012	Korea	Korean	11.2 ± 3.6/10.8 ± 3.9	113/137	Rome III	Single base primer extension assay	102	37	39	26	148	35	79	34	0.41	8
Chung et al. [38]	2014	Korea	Korean	46.8 ± 15.7/50.5 ± 11.1	62/69	Rome III	PCR-RFLP	50	5	27	18	81	15	51	15	0.02	8
Hwang et al. [39]	2014	Korea	Korean	50/54	147/234	Rome III	PCR-RFLP	111	20	62	29	269	64	132	73	0.77	6

HWE, Hardy-Weinberg equilibrium; NOS, Newcastle-Ottawa Scale.