Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage
Table 2
Baseline characteristics of the participants in different subjects groups.
Parameters
Control ()
NAFLD ()
Hepatitis ()
Cirrhosis
Child-Pugh class A
Child-Pugh class B
Child-Pugh class C
()
()
()
Age (yr)
47.4 ± 9.7
43.5 ± 11.4
47.0 ± 10.6
49.0 ± 12.8
50.7 ± 11.7
56.1 ± 9.2
Sex (M/F)
32/28
17/6
22/15
75/6
21/9
16/6
Viral hepatitis (hbv/hcv)
No
No
29/8
75/6
28/2
18/4
Albumin (g/L)
46.7 ± 3.6
48.0 ± 2.6
47.0 ± 3.1
41.3 ± 5.
33.1 ± 4.
30.0 ± 5.
Bilirubin (μmol/L)
Median
11.7
12.5
12.4
15.
21.
114.
Interquartile range
9.0–15.2
8.0–17.3
10.9–16.3
11.6–21.7
12.3–29.7
52.0–308.6
AST (U/L)
Median
17.5
40.
24.
25.
37.
47.
Interquartile range
14.0–20.8
36.0–57.0
20.0–26.0
21.0–40.0
29.0–62.3
38.0–120.0
ALT (U/L)
Median
17.5
66.
20.
26.
34.
24.
Interquartile range
12.5–24.0
58.0–95.0
15.0–25.0
17.5–39.5
26.8–43.0
18.0–75.2
Creatinine (μmol/L)
68.5 ± 12.1
70.1 ± 17.9
72.0 ± 12.3
74.1 ± 14.1
73.9 ± 17.4
84.1 ± 13.
PT (s)
11.5 ± 0.6
11.5 ± 0.7
11.6 ± 0.6
12.3 ± 1.
13.5 ± 1.
19.4 ± 5.
INR
1.0 ± 0.1
1.0 ± 0.1
1.0 ± 0.1
1.1 ± 0.
1.2 ± 0.
1.7 ± 0.
Child-Pugh score
n.a.
n.a.
n.a.
5.2 ± 0.4
7.5 ± 0.7†
11.0 ± 1.
MELD score
n.a.
n.a.
n.a.
7.9 ± 1.9
10.5 ± 3.
21.3 ± 12.
Continuous variables are expressed as means ± standard deviation, or median and interquartile. M: male; F: female; hbv: hepatitis B virus; hcv: hepatitis C virus; n.a.: not available; MELD: model for end stage liver disease. compared with control group; compared with NAFLD group. compared with hepatitis group; compared with Child-Pugh class A group. compared with Child-Pugh class B group.
