Review Article
Duodenal Rare Neuroendocrine Tumor: Clinicopathological Characteristics of Patients with Gangliocytic Paraganglioma
Table 1
Immunohistochemical findings in each tumor component of gangliocytic paraganglioma.
| | Immunohistochemical marker | Epithelioid cells
| Spindle-shaped cells | Ganglion-like cells |
| | Bcl-2 | 16.7% (2/12) | 58.33% (7/12) | 36.36% (4/11) | | Calcitonin | 20.8% (5/24) | 20.0% (4/20) | 21.05% (4/19) | | CD34 | 0% (0/2) | 33.33% (1/3) | 0% (0/1) | | CD56 | 100% (27/27) | 50% (9/18) | 100% (19/19) | | Chromogranin A | 74.8% (98/131) | 8.8% (9/102) | 28.9% (28/97) | | Cytokeratins | 58.8% (50/85) | 6.0% (4/67) | 3.0% (2/66) | | C-kit | 0% (0/8) | 0% (0/8) | 16.7% (4/11) | | Corticotropin | 0% (0/0) | 0% (0/3) | 0% (0/2) | | Estrogen receptor | 23.1% (3/13) | 0% (0/12) | 0% (0/11) | | Gastrin | 4.5% (3/67) | 0% (0/62) | 0% (0/60) | | Glucagon | 6.1% (3/49) | 0% (0/44) | 2.3% (1/43) | | Insulin | 4.3% (2/47) | 0% (0/42) | 0% (0/41) | | Neurofilament | 21.7% (15/69) | 69.1% (47/68) | 27.3% (18/66) | | Neuron-specific enolase | 95.7% (90/94) | 85.0% (68/80) | 87.0% (80/92) | | p53 | 0% (0/13) | 0% (0/12) | 0% (0/11) | | Progesterone receptor | 93.3% (14/15) | 0% (0/12) | 0% (0/12) | | Pancreatic polypeptide | 91.5% (86/94) | 0% (0/83) | 32.1% (27/84) | | S-100 | 10.2% (13/128) | 96.6% (144/149) | 23.9% (28/117) | | Serotonin | 20.0% (12/60) | 1.5% (1/66) | 16.7% (9/54) | | Somatostatin | 82.6% (76/92) | 8.7% (6/69) | 51.3% (41/80) | | Synaptophysin | 96.2% (76/79) | 54.4% (31/57) | 98.4% (61/62) | | Vimentin | 37.5% (3/8) | 60.0% (3/5) | 25.0% (1/4) | | Vasoactive intestinal peptide | 12.1% (4/33) | 13.3% (4/30) | 10.3% (3/29) |
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The positive or negative rates in the extracted cases of duodenal gangliocytic paraganglioma are summarized. Listing in alphabetical number.
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