Clinicopathologic Significance of Extranodal Tumor Extension in Colorectal Adenocarcinoma with Regional Lymph Node Metastasis

Table 3

Univariable and multivariable analyses in colorectal adenocarcinoma with regional lymph node metastasis ().

Variable	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Overall survival
ENTE (absent versus present)	2.484 (1.603–3.848)	<0.001	1.676 (1.065–2.637)	0.026
Vascular invasion	3.095 (2.034–4.710)	<0.001	2.469 (1.595–3.822)	<0.001
Perineural invasion	1.806 (1.086–3.002)	0.023	1.078 (0.631–1.841)	0.785
Tumor deposit	3.778 (2.477–5.763)	<0.001	2.850 (1.839–4.416)	<0.001
Tumor budding (low grade versus high grade)	1.990 (1.284–3.084)	0.002	1.704 (1.087–2.672)	0.020
Disease-free survival
ENTE (absent versus present)	1.866 (1.171–2.973)	0.009	1.357 (0.821–2.244)	0.234
Vascular invasion	2.967 (1.858–4.738)	<0.001	1.211 (0.722–2.029)	0.468
Perineural invasion	1.410 (0.834–2.384)	0.200	1.154 (0.651–2.042)	0.624
Tumor deposit	2.205 (1.373–3.542)	<0.001	0.937 (0.556–1.580)	0.807
Tumor budding (low grade versus high grade)	1.244 (0.769–2.012)	0.375	0.888 (0.524–1.503)	0.658

HR: hazard ratio; CI: confidence interval; ENTE: extranodal tumor extension.