The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription

Figure 3

High frequency of LOH at all tested loci in 22 sporadic MSS colorectal cancers (12 with nuclear and 10 with membranous β-catenin) indicates significant role of the differentially expressed genes in carcinogenesis.