Suppressing Syndecan-1 Shedding Ameliorates Intestinal Epithelial Inflammation through Inhibiting NF-κB Pathway and TNF-α
TNF-α and IL-1β secretions in IEC-6 cells were assessed by ELISA and q-PCR. LPS was used to induce secretions of TNF-α and IL-1β. (a), (b) SDC1 lessened secretions of TNF-α upon LPS stimulation. The decreases induced by unshedding SDC1 were more notable (). (c), (d) However, no significant change was observed in IL-1β.
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