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Gastroenterology Research and Practice
Volume 2016, Article ID 6718590, 6 pages
http://dx.doi.org/10.1155/2016/6718590
Research Article

Association of Tissue Transglutaminase Antibody Titer with Duodenal Histological Changes in Children with Celiac Disease

1Department of Pediatrics, Hashemite University, P.O. Box 1504514, Zarqa 13115, Jordan
2Department of Pediatrics, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, Jordan
3Department of Pathology, Prince Hamzah Hospital, P.O. Box 86, Amman 11118, Jordan

Received 7 April 2016; Revised 4 July 2016; Accepted 26 July 2016

Academic Editor: David Bernardo

Copyright © 2016 Hasan Hawamdeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Celiac disease is usually diagnosed by demonstrating gluten enteropathy in small bowel biopsy. Celiac specific antibodies are used as an initial screening test. The goal of this study is to test the relationship of the anti-tTG titer and severity of histological changes in Jordanian children with celiac disease. Method. The medical records of 81 children who had elevated anti-tTG titer and had duodenal biopsies available were retrospectively reviewed. Result. Assessing the association of anti-tTG titer with duodenal histopathological changes, 94% of those with high anti-tTG titer (≥180 U/mL) had histological evidence of celiac disease. There was statistically significant positive association between high anti-tTG titer and Marsh grading as 82% of patients with Marsh III had high anti-tTG titer (Chi2 18.5; P value 0.00; Odds Ratio 8.5). The fraction of patients with Marsh III who were correctly identified as positive by anti-tTG titer ≥ 180 U/mL was high (sensitivity = 81.6). Moreover, the fraction of patients with anti-tTG titer ≥ 180 U/mL who had Marsh III was also high (positive predictive value = 78.4). Conclusion. Anti-tTG titer ≥ 180 U/mL had significant positive association with Marsh III histopathological changes of celiac disease.