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Gastroenterology Research and Practice
Volume 2016, Article ID 8743187, 8 pages
http://dx.doi.org/10.1155/2016/8743187
Research Article

Postoperative Albumin Drop Is a Marker for Surgical Stress and a Predictor for Clinical Outcome: A Pilot Study

Department of Visceral Surgery and Transplantation and Department of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland

Received 18 September 2015; Revised 26 November 2015; Accepted 29 November 2015

Academic Editor: Miguel Pera

Copyright © 2016 Martin Hübner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Buunen, M. Gholghesaei, R. Veldkamp, D. W. Meijer, H. J. Bonjer, and N. D. Bouvy, “Stress response to laparoscopic surgery: a review,” Surgical Endoscopy and Other Interventional Techniques, vol. 18, no. 7, pp. 1022–1028, 2004. View at Google Scholar · View at Scopus
  2. J. P. Desborough, “The stress response to trauma and surgery,” British Journal of Anaesthesia, vol. 85, no. 1, pp. 109–117, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Haga, T. Beppu, K. Doi et al., “Systemic inflammatory response syndrome and organ dysfunction following gastrointestinal surgery,” Critical Care Medicine, vol. 25, no. 12, pp. 1994–2000, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Hall, “Identification of inflammatory mediators and their modulation by strategies for the management of the systemic inflammatory response during cardiac surgery,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 27, no. 5, pp. 983–1033, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Karanika, T. Karantanos, and G. E. Theodoropoulos, “Immune response after laparoscopic colectomy for cancer: a review,” Gastroenterology Report, vol. 1, no. 2, pp. 85–94, 2013. View at Publisher · View at Google Scholar
  6. E. Lin, S. E. Calvano, and S. F. Lowry, “Inflammatory cytokines and cell response in surgery,” Surgery, vol. 127, no. 2, pp. 117–126, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. P. E. Marik and M. Flemmer, “The immune response to surgery and trauma: implications for treatment,” Journal of Trauma and Acute Care Surgery, vol. 73, no. 4, pp. 801–808, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. M. E. Coolsen, R. M. van Dam, A. A. van der Wilt, K. Slim, K. Lassen, and C. H. C. Dejong, “Systematic review and meta-analysis of enhanced recovery after pancreatic surgery with particular emphasis on pancreaticoduodenectomies,” World Journal of Surgery, vol. 37, no. 8, pp. 1909–1918, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Greco, G. Capretti, L. Beretta, M. Gemma, N. Pecorelli, and M. Braga, “Enhanced recovery program in colorectal surgery: a meta-analysis of randomized controlled trials,” World Journal of Surgery, vol. 38, no. 6, pp. 1531–1541, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Muller, M. P. Zalunardo, M. Hubner, P. A. Clavien, and N. Demartines, “A fast-track program reduces complications and length of hospital stay after open colonic surgery,” Gastroenterology, vol. 136, no. 3, pp. 842–847, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Karaman, E. B. Bostanci, E. Aksoy et al., “Effects of dexamethasone and pheniramine hydrogen maleate on stress response in patients undergoing elective laparoscopic cholecystectomy,” American Journal of Surgery, vol. 205, no. 2, pp. 213–219, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. E. Kilger, J. Heyn, A. Beiras-Fernandez, B. Luchting, and F. Weis, “Stress doses of hydrocortisone reduce systemic inflammatory response in patients undergoing cardiac surgery without cardiopulmonary bypass,” Minerva Anestesiologica, vol. 77, no. 3, pp. 268–274, 2011. View at Google Scholar · View at Scopus
  13. L. A. Orci, C. Toso, G. Mentha, P. Morel, and P. E. Majno, “Systematic review and meta-analysis of the effect of perioperative steroids on ischaemia-reperfusion injury and surgical stress response in patients undergoing liver resection,” British Journal of Surgery, vol. 100, no. 5, pp. 600–609, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. N. H. Waldron, C. A. Jones, T. J. Gan, T. K. Allen, and A. S. Habib, “Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis,” British Journal of Anaesthesia, vol. 110, no. 2, pp. 191–200, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Thorell, S. Efendic, M. Gutniak, T. Haggmark, and O. Ljungqvist, “Development of postoperative insulin resistance is associated with the magnitude of operation,” European Journal of Surgery, Acta Chirurgica, vol. 159, no. 11-12, pp. 593–599, 1993. View at Google Scholar · View at Scopus
  16. A. Thorell, J. Nygren, and O. Ljungqvist, “Insulin resistance: a marker of surgical stress,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 2, no. 1, pp. 69–78, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Easton and Z. J. Balogh, “Peri-operative changes in serum immune markers after trauma: a systematic review,” Injury, vol. 45, no. 6, pp. 934–941, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Warschkow, U. Beutner, T. Steffen et al., “Safe and early discharge after colorectal surgery due to C-reactive protein: a diagnostic meta-analysis of 1832 patients,” Annals of Surgery, vol. 256, no. 2, pp. 245–250, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Lelubre, S. Anselin, K. Zouaoui Boudjeltia, P. Biston, and M. Piagnerelli, “Interpretation of c-reactive protein concentrations in critically Ill patients,” BioMed Research International, vol. 2013, Article ID 124021, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Fleck, G. Raines, F. Hawker et al., “Increased vascular permeability: a major cause of hypoalbuminaemia in disease and injury,” The Lancet, vol. 325, no. 8432, pp. 781–784, 1985. View at Publisher · View at Google Scholar
  21. A. M. Ryan, A. Hearty, R. S. Prichard, A. Cunningham, S. P. Rowley, and J. V. Reynolds, “Association of hypoalbuminemia on the first postoperative day and complications following esophagectomy,” Journal of Gastrointestinal Surgery, vol. 11, no. 10, pp. 1355–1360, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. H. J. Smeets, J. Kievit, F. T. Dulfer, J. Hermans, and A. J. Moolenaar, “Analysis of post-operative hypalbuminaemia: a clinical study,” International Surgery, vol. 79, no. 2, pp. 152–157, 1994. View at Google Scholar · View at Scopus
  23. D. Dindo, N. Demartines, and P.-A. Clavien, “Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey,” Annals of Surgery, vol. 240, no. 2, pp. 205–213, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Cerantola, M. Hübner, F. Grass, N. Demartines, and M. Schäfer, “Immunonutrition in gastrointestinal surgery,” British Journal of Surgery, vol. 98, no. 1, pp. 37–48, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. J. H. Park, D. C. McMillan, P. G. Horgan, and C. S. Roxburgh, “The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer,” Cancer Treatment Reviews, vol. 40, no. 1, pp. 68–77, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Bugada, M. Allegri, P. Lavand'Homme, M. De Kock, and G. Fanelli, “Inflammation-based scores: a new method for patient-targeted strategies and improved perioperative outcome in cancer patients,” BioMed Research International, vol. 2014, Article ID 142425, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. A. G. Hill and G. L. Hill, “Metabolic response to severe injury,” British Journal of Surgery, vol. 85, no. 7, pp. 884–890, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. J. A. Russell, “Management of sepsis,” The New England Journal of Medicine, vol. 355, no. 16, pp. 1699–1713, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. P. A. Kern, S. Ranganathan, C. Li, L. Wood, and G. Ranganathan, “Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance,” American Journal of Physiology—Endocrinology and Metabolism, vol. 280, no. 5, pp. E745–E751, 2001. View at Google Scholar · View at Scopus
  30. J. Spranger, A. Kroke, M. Möhlig et al., “Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study,” Diabetes, vol. 52, no. 3, pp. 812–817, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Vozarova, C. Weyer, K. Hanson, P. A. Tataranni, C. Bogardus, and R. E. Pratley, “Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion,” Obesity Research, vol. 9, no. 7, pp. 414–417, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Glund and A. Krook, “Role of interleukin-6 signalling in glucose and lipid metabolism,” Acta Physiologica, vol. 192, no. 1, pp. 37–48, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. G. van Hall, A. Steensberg, M. Sacchetti et al., “Interleukin-6 stimulates lipolysis and fat oxidation in humans,” The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 7, pp. 3005–3010, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Hülshoff, T. Schricker, H. Elgendy, R. Hatzakorzian, and R. Lattermann, “Albumin synthesis in surgical patients,” Nutrition, vol. 29, no. 5, pp. 703–707, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Dutta, A. B. C. Crumley, G. M. Fullarton, P. G. Horgan, and D. C. McMillan, “Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative resection of oesophageal cancer,” World Journal of Surgery, vol. 35, no. 8, pp. 1861–1866, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. D. C. McMillan, “The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer,” Cancer Treatment Reviews, vol. 39, no. 5, pp. 534–540, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Ishizuka, H. Nagata, K. Takagi, Y. Iwasaki, N. Shibuya, and K. Kubota, “Clinical significance of the C-reactive protein to albumin ratio for survival after surgery for colorectal cancer,” Annals of Surgical Oncology, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  38. O. T. Ranzani, F. G. Zampieri, D. N. Forte, L. C. P. Azevedo, and M. Park, “C-reactive protein/albumin ratio predicts 90-day mortality of septic patients,” PLoS ONE, vol. 8, no. 3, Article ID e59321, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. D. W. Hart, S. E. Wolf, R. Mlcak et al., “Persistence of muscle catabolism after severe burn,” Surgery, vol. 128, no. 2, pp. 312–319, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Rittler, R. Jacobs, H. Demmelmair et al., “Dynamics of albumin synthesis after major rectal operation,” Surgery, vol. 141, no. 5, pp. 660–666, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Fleck, C. M. Colley, and M. A. Myers, “Liver export proteins and trauma,” British Medical Bulletin, vol. 41, no. 3, pp. 265–273, 1985. View at Google Scholar · View at Scopus
  42. W. L. Lee and A. S. Slutsky, “Sepsis and endothelial permeability,” The New England Journal of Medicine, vol. 363, no. 7, pp. 689–691, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Caironi, G. Tognoni, S. Masson et al., “Albumin replacement in patients with severe sepsis or septic shock,” The New England Journal of Medicine, vol. 370, no. 15, pp. 1412–1421, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Weimann, M. Braga, L. Harsanyi et al., “ESPEN Guidelines on Enteral Nutrition: surgery including organ transplantation,” Clinical Nutrition, vol. 25, no. 2, pp. 224–244, 2006. View at Publisher · View at Google Scholar · View at Scopus