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Gastroenterology Research and Practice
Volume 2016, Article ID 9251375, 11 pages
Review Article

Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?

1University of Pittsburgh, Pittsburgh, PA 15213, USA
2Mayo Clinic, Scottsdale, AZ 85259, USA
3MD Anderson Cancer Center, Houston, TX 77030, USA

Received 20 December 2015; Accepted 16 February 2016

Academic Editor: Nicola Silvestris

Copyright © 2016 Amol Mehta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Percutaneous image-guided ablation is an increasingly common treatment for a multitude of solid organ malignancies. While historically these techniques have been restricted to the management of small, unresectable tumors, there is an expanding appreciation for the systemic effects these locoregional interventions can cause. In this review, we summarize the mechanisms of action for the most common thermal ablation modalities and highlight the key advances in knowledge regarding the interactions between thermal ablation and the immune system.